Target ACE2, Spike protein

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ACE2; any specific functions of spike protein; see also RSP - On RAS drugs

GET 2020. SARS-CoV-2 spike glycoprotein-binding proteins expressed by upper respiratory tract bacteria may prevent severe viral infection. Extract


regulation of ace2

  • GET ä. EZH2-mediated H3K27me3 inhibits ACE2 expression Extract
  • GET 2020. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations Extract
  • GET 2020. (ACE2) Does a cell protein explain covid-19 severity? Extract
  • GET 2020. Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor Extract
GET 2020. A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance Extract
  • GET 2020. Alternative splicing of ACE2 possibly generates variants that may limit the entry of SARS-CoV-2: a potential therapeutic approach using SSOs. Extract

ace2 species specificity clade specificity

  • GET 2020. Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV Extract
  • GET ä. Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2 Extract
  • GET ä. Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS?CoV?2 Extract
  • GET ä. Structural variations in human ACE2 may influence its binding with SARS?CoV?2 spike protein Extract
  • GET 2020. SARS-CoV-2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein Extract
  • GET ä. SARS?CoV?2 spike protein favors ACE2 from Bovidae and Cricetidae Extract
  • GET 2020. ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2. Extract


any receptors in target tissues

  • GET ä. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses Extract


ACE2 expression in target tissues

  • GET 2020. The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies. Extract
  • GET 2020. In vitro analysis of the renin-angiotensin system and inflammatory gene transcripts in human bronchial epithelial cells after infection with severe acute respiratory syndrome coronavirus. Extract
  • GET ä. Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection? Extract
  • GET 2020. ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia Extract
  • GET ä. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 Extract
  • GET 2020. Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter? Extract
  • GET ä. Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2 Mediated COVID-19 Extract
  • GET 2020. Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells. Extract
  • GET 2020. Expression of SARS-CoV-2 Receptor ACE2 and Coincident Host Response Signature Varies by Asthma Inflammatory Phenotype. Extract
  • GET 2020. Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis. Extract
  • GET 2020. Which cancer type has the highest risk of COVID-19 infection? Extract
  • GET 2020. High expression of ACE2 on the keratinocytes reveals skin as a potential target for SARS-CoV-2. Extract
  • GET 2020. Age, inflammation and disease location are critical determinants of intestinal expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in inflammatory bowel disease. Extract
  • GET 2020. ACE2 correlated with immune infiltration serves as a prognostic biomarker in endometrial carcinoma and renal papillary cell carcinoma: implication for COVID-19. Extract
  • GET 2020. A profiling analysis on the receptor ACE2 expression reveals the potential risk of different type of cancers vulnerable to SARS-CoV-2 infection. Extract
GET 2020. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Extract
  • GET 2020. ACE2 expression and sex disparity in COVID-19. Extract
  • GET 2020. Elevated expression of ACE2 in tumor-adjacent normal tissues of cancer patients. Extract
  • GET 2020. ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19. Extract

ace2 amplification

  • GET 2020. An update on ACE2 amplification and its therapeutic potential. Extract

soluble ace2

  • GET 2020. COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women and Children. Extract
  • GET 2020. Age and sex differences in soluble ACE2 may give insights for COVID-19. Extract
  • GET 2020. Truncated human angiotensin converting enzyme 2; a potential inhibitor of SARS-CoV-2 spike glycoprotein and potent COVID-19 therapeutic agent. Extract
  • GET ä. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 Extract
  • GET 2020. Could the smoking gun in the fight against Covid-19 be the (rh) ACE2? Extract
  • GET 2020. Inhaled modified angiotensin converting enzyme 2 (ACE2) as a decoy to mitigate SARS-CoV-2 infection. Extract


Structure spike/ace2

GET 2020. Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19. Extract
GET 2020. Functional prediction and frequency of coding variants in human ACE2 at binding sites with SARS-CoV-2 spike protein on different populations. Extract
  • GET 2020. Structural and simulation analysis of hotspot residues interactions of SARS-CoV 2 with human ACE2 receptor. Extract
  • GET 2020. Conserved High Free Energy Sites in Human Coronavirus Spike Glycoprotein Backbones. Extract
GET 2020. Comparison of SARS-CoV-2 spike protein binding to ACE2 receptors from human, pets, farm animals, and putative intermediate hosts. Extract
cattle and sheep...
  • GET 2020. Comparing the Binding Interactions in the Receptor Binding Domains of SARS-CoV-2 and SARS-CoV. Extract
  • GET 2020. Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site. Extract
  • GET 2020. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade Extract
  • GET 2020. Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site. Extract
  • GET 2020. Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions. Extract
  • GET ä. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein Extract
  • GET 2020. Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 Extract
  • GET ä. Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop Extract
  • GET 2020. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission Extract
  • GET 2020. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Extract
  • GET 2020. Structure analysis of the receptor binding of 2019-nCoV Extract
  • GET 2020. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Extract
  • GET ä. Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine Extract
  • GET ä. Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2 Extract
  • GET ä. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection Extract
  • GET 2020. Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis Extract
  • GET ä. Covid-19 and the angiotensin-converting enzyme (ACE2): Areas for research Extract
GET 2020. A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin Extract
  • GET 2020. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus Extract
GET ä. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells Extract
  • GET 2020. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV Extract
GET 2020. Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry Extract
  • GET 2020. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV Extract
GET ä. Site-specific glycan analysis of the SARS-CoV-2 spike Extract
  • GET 2020. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 Extract
  • GET ä. A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility Extract
  • GET 2020. The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor Extract
  • GET 2020. A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivity Extract
  • GET 2020. Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV Extract
  • GET 2020. Focus on Receptors for Coronaviruses with Special Reference to Angiotensin-converting Enzyme 2 as a Potential Drug Target - A Perspective Extract
  • GET ä. Deducing the N- and O- glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2 Extract
GET 2020. SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate Extract
  • GET 2020. Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein Extract
  • GET 2020. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor Extract
  • GET 2020. Structural basis of receptor recognition by SARS-CoV-2 Extract
  • GET 2020. Spike protein in the detection and treatment of novel coronavirus Extract
  • GET ä. The biological characteristics of SARS-CoV-2 spike protein Pro330-Leu650 Extract
  • GET ä. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Extract
  • GET 2020. ANNALS EXPRESS: Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: a closer look at angiotensin-converting enzyme 2 (ACE2) Extract
  • GET 2020. ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel? Extract
  • GET 2020. Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: A double-edged sword? Extract
  • GET 2020. Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality? Extract
  • GET 2020. In silico studies on the comparative characterization of the interactions of SARS-CoV-2 spike glycoprotein with ACE-2 receptor homologs and human TLRs. Extract
  • GET 2020. Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? Insights from All-Atom Simulations. Extract
  • GET 2020. Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: A computational biology approach. Extract
  • GET 2020. Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism. Extract
  • GET 2020. Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Extract
  • GET 2020. Identification of 22 N-glycosites on spike glycoprotein of SARS-CoV-2 and accessible surface glycopeptide motifs: implications for vaccination and antibody therapeutics. Extract


Drug design

GET 2020. Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2. Extract
GET 2020. COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles? heel conserved region to minimize probability of escape mutations and drug resistance Extract
  • GET ä. Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2 Extract
  • GET 2020. Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming. Extract
  • GET 2020. In Silico computational screening of Kabasura Kudineer - Official Siddha Formulation and JACOM against SARS-CoV-2 spike protein. Extract
  • GET 2020. Inhibition of SARS-CoV-2 infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion Extract
  • GET ä. Blockade of SARS-CoV-2 infection by recombinant soluble ACE2 Extract
  • GET ä. SARS-CoV-2 infection of kidney organoids prevented with soluble human ACE2 Extract
  • GET ä. A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease Extract
  • GET 2020. Off-target ACE2 ligands: Possible therapeutic option for CoVid-19? Extract
  • GET 2020. Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy? Extract
  • GET 2020. In silico screening of natural compounds against COVID-19 by targeting Mpro and ACE2 using molecular docking Extract
  • GET 2020. CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19) Extract
  • GET 2020. In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria Extract
  • GET 2020. An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets Extract
  • GET 2020. ACE2 Activators for the Treatment of Covid 19 Patients Extract
  • GET 2020. Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig Extract
  • GET 2020. Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity Extract
  • GET ä. In Silico Design of Antiviral Peptides Targeting the Spike Protein of SARS-CoV-2 Extract
GET ä. Isolation of a human monoclonal antibody specific for the receptor binding domain of SARS-CoV-2 using a competitive phage biopanning strategy Extract
GET ä. Inhibition of SARS-CoV-2 infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion Extract
Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection
  • GET 2012. Design of Angiotensin?converting Enzyme 2 (ACE2) Inhibitors by Virtual Lead Optimization and Screening Extract
  • GET 2020. In silico design of antiviral peptides targeting the spike protein of SARS-CoV-2 Extract
  • GET 2020. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody Extract
  • GET ä. Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV Extract
  • GET ä. Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor Extract
  • GET ä. A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization Extract
  • GET 2020. The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues. Extract
  • GET 2020. Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidity. Extract
  • GET 2020. Identification of a Potential Peptide Inhibitor of SARS-CoV-2 Targeting its Entry into the Host Cells. Extract
  • GET 2020. Discovery of Aptamers Targeting Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein. Extract
  • GET 2020. Blocking Coronavirus 19 Infection via the SARS-CoV-2 Spike Protein: Initial Steps. Extract
  • GET 2020. Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) Viral Spike Protein-Angiotensin Converting Enzyme-2 (ACE2) interaction. Extract
  • GET 2020. Eltrombopag is a potential target for drug intervention in SARS-CoV-2 spike protein. Extract
  • GET 2020. Identification of bioactive compounds from Glycyrrhiza glabra as possible inhibitor of SARS-CoV-2 spike glycoprotein and non-structural protein-15: a pharmacoinformatics study. Extract
GET 2020. Targeting the SARS-CoV-2 spike glycoprotein prefusion conformation: virtual screening and molecular dynamics simulations applied to the identification of potential fusion inhibitors. Extract
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