Spontaneous idea: magnesium and hydroxychloroquine

(Unterschied zwischen Versionen)
Wechseln zu: Navigation, Suche
K
K
Zeile 5: Zeile 5:
 
Since my best bet since 02/2020 is magnesium, my brain cell said 10 in ago WOW.
 
Since my best bet since 02/2020 is magnesium, my brain cell said 10 in ago WOW.
  
The literature on Mg AND hcq/cq shows only binding of drug to magnesium particles i.e. in antacids, but no prophylactic use to circumvent this functional toxicity:
+
The literature on Mg AND hcq/cq shows only binding of drug to magnesium particles i.e. in antacids, but no prophylactic use to circumvent this  
  
http://www.moremed.org/SiteSearch.php?S1=%22mg2%2B%22+OR+magnesium+OR+mgso4+OR+hypomagnes*+OR+hypermagnes*+OR+trpm7&S2=chloroquine+OR+hydroxychloroquine&S3=&submit=submit&px1=proxy.nationallizenzen.de&px2=&px3=&px4=&R=all&Y0=1500&Y1=2025
+
functional toxicity:  
  
 
Known effects of Mg on QTc/tdp
 
Known effects of Mg on QTc/tdp
 
http://www.moremed.org/SiteSearch.php?S1=QT+time+OR+QT+prolongation+OR+QT+dispersion+OR+QT+time+OR+QT+prolongation+OR+QT+dispersion+OR+OR+lqt*+OR+long+qt+OR+early+afterdepolari*+OR+early+after-depolari*+OR+torsade+de+pointes+OR+%22kir2.1%22+OR+%22kv4.2%22+OR+hERG&S2=%22mg2%2B%22+OR+magnesium+OR+mgso4+OR+hypomagnes*+OR+hypermagnes*+OR+trpm7&S3=&submit=submit&px1=proxy.nationallizenzen.de&px2=&px3=&px4=&R=all&Y0=1500&Y1=2025
 
  
 
Effects of clq on QTc time prolongation as it is an established high-efficiency drug.
 
Effects of clq on QTc time prolongation as it is an established high-efficiency drug.
  
http://www.moremed.org/SiteSearch.php?S1=QT+time+OR+QT+prolongation+OR+QT+dispersion+OR+QT+time+OR+QT+prolongation+OR+QT+dispersion+OR+OR+lqt*+OR+long+qt+OR+early+afterdepolari*+OR+early+after-depolari*+OR+torsade+de+pointes+OR+%22kir2.1%22+OR+%22kv4.2%22+OR+hERG&S2=chloroquine+OR+hydroxychloroquine&S3=&submit=submit&px1=proxy.nationallizenzen.de&px2=&px3=&px4=&R=all&Y0=1500&Y1=2025
+
searchterms & selected results here [[Bibliography Magnesium QTC HCQ]]
  
 +
another idea very old concept hcq as dna tropic agent whether it does anything w. net's
  
 +
[[Bibliography Extracellular Traps - HCQ]]
  
another idea very old concept hcq as dna tropic agent whether it does anything w. net's
+
and a pretty one
 
+
http://www.moremed.org/SiteSearch.php?S1=extracellular+traps+OR+netosis+OR+neutrophil+extracellular+traps+OR+eosinophil+extracellular+traps&S2=chloroquine+OR+hydroxychloroquine&S3=&submit=submit&px1=proxy.nationallizenzen.de&px2=&px3=&px4=&R=all&Y0=1500&Y1=2025
+
  
 
{{ttp|p=32437924|t=2020. Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates  hepatic ischemia/reperfusion injury by blocking TLR9 in mice |pdf=|usr=}}
 
{{ttp|p=32437924|t=2020. Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates  hepatic ischemia/reperfusion injury by blocking TLR9 in mice |pdf=|usr=}}
Zeile 27: Zeile 25:
 
Tomorrow we will know if Hydroxychloroquine could be made a safe drug by oral magnesium substitution - with phased application of mg and hcq bc inactivation of hcq by mere binding each other.
 
Tomorrow we will know if Hydroxychloroquine could be made a safe drug by oral magnesium substitution - with phased application of mg and hcq bc inactivation of hcq by mere binding each other.
  
'''By scanning lower quality search terms the concept seems to be appropriate. Substitute Magnesium in case of application of any QTc prolonging drug such as Hydroxychloroquine or Azithromycin or any of many . Much literature work to 'prove' it.'''
+
'''By preliminary scanning lower quality search terms the concept seems to be appropriate. Substitute Magnesium in case of application of any QTc prolonging drug such as Hydroxychloroquine or Azithromycin or any of many . Much literature work to 'prove' it.'''
 
+
[[Bibliography Magnesium QTC HCQ]]
+

Version vom 10. August 2020, 07:22 Uhr

The most limiting adverse effect of hcq is cardiac arrythmia caused by qt time prolongation driving torsade de pointes, ventricular fibrillation and asystolic death, ultimately.

I remembered mgso4 is drug of choice in tdp, adjusting the qtc to normal.

Since my best bet since 02/2020 is magnesium, my brain cell said 10 in ago WOW.

The literature on Mg AND hcq/cq shows only binding of drug to magnesium particles i.e. in antacids, but no prophylactic use to circumvent this

functional toxicity:

Known effects of Mg on QTc/tdp

Effects of clq on QTc time prolongation as it is an established high-efficiency drug.

searchterms & selected results here Bibliography Magnesium QTC HCQ

another idea very old concept hcq as dna tropic agent whether it does anything w. net's

Bibliography Extracellular Traps - HCQ

and a pretty one

32437924 2020. Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates hepatic ischemia/reperfusion injury by blocking TLR9 in mice

Tomorrow we will know if Hydroxychloroquine could be made a safe drug by oral magnesium substitution - with phased application of mg and hcq bc inactivation of hcq by mere binding each other.

By preliminary scanning lower quality search terms the concept seems to be appropriate. Substitute Magnesium in case of application of any QTc prolonging drug such as Hydroxychloroquine or Azithromycin or any of many . Much literature work to 'prove' it.

Meine Werkzeuge
Namensräume
Varianten
Aktionen
Navigation
Werkzeuge
Blogverzeichnis - Blog Verzeichnis bloggerei.deBlogverzeichnis