Spontaneous idea: magnesium and hydroxychloroquine
The most limiting adverse effect of hcq is cardiac arrythmia caused by qt time prolongation driving torsade de pointes, ventricular fibrillation and asystolic death, ultimately.
I remembered mgso4 is drug of choice in tdp, adjusting the qtc to normal.
Since my best bet since 02/2020 is magnesium, my brain cell said 10 in ago WOW.
The literature on Mg AND hcq/cq shows only binding of drug to magnesium particles i.e. in antacids, but no prophylactic use to circumvent this
functional toxicity:
Known effects of Mg on QTc/tdp
Effects of clq on QTc time prolongation as it is an established high-efficiency drug.
searchterms & selected results here
another idea very old concept hcq as dna tropic agent whether it does anything w. net's
Bibliography Extracellular Traps - HCQ
and a pretty one
| 32437924 2020. Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates hepatic ischemia/reperfusion injury by blocking TLR9 in mice |
Tomorrow we will know if Hydroxychloroquine could be made a safe drug by oral magnesium substitution - with phased application of mg and hcq bc inactivation of hcq by mere binding each other.
By preliminary scanning lower quality search terms the concept seems to be appropriate. Substitute Magnesium in case of application of any QTc prolonging drug such as Hydroxychloroquine or Azithromycin or any of many . Much literature work to 'prove' it.
