Other single compounds

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Thymosin

GET 2020. Thymosin alpha 1 (Talpha1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells. Extract

Thymoquinone

  • GET 2020. Covid-19 and Thymoquinone: Connecting the Dots. Extract

G-CSF, GM-CSF

  • GET 2020. Granulocyte-colony stimulating factor in COVID-19: Is it stimulating more than just the bone marrow? Extract
  • GET 2020. GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches. Extract
  • GET 2020. Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. Extract


hzVSF‐v13 Humanized virus suppressing factor‐variant 13 (hzVSF‐v13) is a monoclonal IgG4 against vimentin, which is expressed on the surface of virus‐infected cells.

  • GET 2020. Compassionate use of hzVSF-v13 in two patients with severe COVID-19. Extract

Omalizumab

  • GET 2020. Omalizumab and COVID19 Treatment: Could It Help? Extract Anti-IgE mab, -IL6,-TNF,-IL1,-NFKB


Almitrine

  • GET 2020. Almitrine as a non-ventilatory strategy to improve intrapulmonary shunt in COVID-19 patients. Extract
  • GET 2020. Effect of almitrine bismesylate and inhaled nitric oxide on oxygenation in COVID-19 acute respiratory distress syndrome. Extract
  • GET 2020. Efficacy of Almitrine in The Treatment of Hypoxemia in Sars-Cov-2 Acute Respiratory Distress Syndrome. Extract


H2S

  • GET 2020. H2S as a potential defence against COVID-19? Extract
  • GET 2020. Possible application of H2S-producing compounds in therapy of coronavirus (COVID-19) infection and pneumonia. Extract


Oleoylethanolamide

  • GET ä. Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19 Extract


Lauric acid nat. compd.



Dipyridamole retarget

  • GET ä. Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19 Extract

CGRP calcitonin gene related peptide antagonists

  • GET 2020. Could CGRP Antagonists Be Helpful in the Fight Against COVID-19? Extract


Various Leads


BRD4 polycomb

  • GET 2020. Targeting SARS-CoV-2 using polycomb inhibitors as antiviral agents. Extract



Ipecac

  • GET 2020. Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses Extract

Sodium pyruvate

  • GET 2020. Inhaled Nebulized Sodium Pyruvate Use in COVID-19 Patients Extract


Ciclesonide

  • GET ä. Therapeutic potential of ciclesonide inhalation for COVID-19 pneumonia: Report of three cases Extract
  • GET 2020. Molecular pharmacology of ciclesonide against SARS-CoV-2. Extract
  • GET 2020. A Case of Coronavirus Disease 2019 Treated With Ciclesonide. Extract



Botox

  • GET ä. Perspectives for the use of therapeutic Botulinum toxin as a multifaceted candidate drug to attenuate COVID-19 Extract



Endothelin antagonists

  • GET 2020. Why not consider an endothelin receptor antagonist against SARS?CoV?2? Extract
  • GET 2020. Endothelin receptor antagonists for pulmonary arterial hypertension and COVID-19: Friend or foe? Extract


Rho kinase inhibitors

  • GET 2020. Plausibility of therapeutic effects of Rho kinase inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19) Extract
  • GET 2020. Rho kinase inhibitors for SARS-CoV-2 induced acute respiratory distress syndrome: Support from Bartter's and Gitelman's syndrome patients. Extract

Saikosaponins

  • GET 2020. Purposing Saikosaponins for the treatment of COVID-19 Extract
  • GET 2020. An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets Extract

ADAM17 as target

  • GET ä. ADAM17 inhibition may exert a protective effect on COVID-19 Extract



Nitazoxanide

  • GET 2020. Review of safety and minimum pricing of nitazoxanide for potential treatment of COVID-19. Extract
  • GET ä. Nitazoxanide/Azithromycin combination for COVID-19: A suggested new protocol for COVID-19 early management Extract

tPA

GET 2020. Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis Extract
GET 2020. Is there a role for tissue plasminogen activator as a novel treatment for refractory COVID-19 associated acute respiratory distress syndrome? Extract
  • GET 2020. Early Outcomes with Utilization of Tissue Plasminogen Activator in COVID-19 Associated Respiratory Distress: A series of five cases. Extract
GET 2020. Rescue Therapy for Severe COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS) with Tissue Plasminogen Activator (tPA): A Case Series. Extract

Plasminogen

  • GET ä. Plasminogen improves lung lesions and hypoxemia in patients with COVID-19 Extract

Hesperidin

  • GET 2020. Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection? Extract

Diacerein

  • GET 2020. Diacerein: A potential multi-target therapeutic drug for COVID-19. Extract

CD147

  • GET ä. CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement Extract

Bee venom


Luteolin

  • GET 2020. COVID-19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin Extract


Pannexin1 channels

  • GET 2020. Consideration of Pannexin 1 channels in COVID-19 pathology and treatment. Extract

NAD+

  • GET 2020. Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesis. Extract

Celastrol

  • GET 2020. Should we try the antiinflammatory natural product, celastrol, for COVID-19? Extract

1

  • GET 2020. A Radiation Mitigator as a Potential Treatment for COVID-19 Extract

Ozone

  • GET ä. (Vitamin-C; Ozone)Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19? Extract
  • GET 2020. Oxygen-ozone therapy as adjuvant in the current emergency in SARS-COV-2 infection: a clinical study. Extract



stimulating the Platelets

GET 2020. Promoting platelets is a therapeutic option to combat severe viral infection of the lung Extract


Thrombomodulin

  • GET 2013. (x)Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome Extract


Lipids

  • GET 2020. Response to: Bioactive Lipids and Coronavirus (COVID-19)-further Discussion. Extract
  • GET 2020. The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target. Extract
  • GET 2020. Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation. Extract
  • GET 2020. Potential COVID-19 therapeutics from a rare disease: Weaponizing lipid dysregulation to combat viral infectivity. Extract

Resolvins

  • GET 2020. Covid-19 management with inflammation resolving mediators? Perspectives and potential Extract



mabs

  • GET 2020. Monoclonal antibody as a potential anti-COVID-19. Extract
  • GET 2020. First antibody against COVID-19 spike protein enters phase I. Extract
  • GET 2020. Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Extract
  • GET 2020. An approach towards development of monoclonal IgY antibodies against SARS CoV-2 spike protein (S) using phage display method: A review. Extract


tlr's

  • GET 2020. Consider TLR5 for new therapeutic development against COVID-19. Extract


lactoferrin

  • GET 2020. Can lactoferrin boost human immunity against COVID-19? Extract



Ursodeoxycholic acid

  • GET 2020. Ursodeoxycholic acid as a candidate therapeutic to alleviate and/or prevent COVID-19-associated cytokine storm. Extract
  • GET 2020. Merit of an Ursodeoxycholic Acid Clinical Trial in COVID-19 Patients. Extract

Diethylcarbamazine anti-filarial

  • GET 2020. Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? Extract

Nitrofurazoxide

GET 2020. A novel role of nifuroxazide in attenuation of sepsis-associated acute lung and myocardial injuries; role of TLR4/NLPR3/IL-1beta signaling interruption. Extract

Parthenolide

  • GET 2020. Cytokine storm in COVID-19 and parthenolide: preclinical evidence. Extract


Lidocaine

  • GET 2020. Nebulized Lidocaine in COVID-19, An Hypothesis. Extract

Escin

  • GET 2020. Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin. Extract

Methioninase

  • GET 2020. Oral Methioninase for Covid-19 Methionine-restriction Therapy. Extract


Thalidomide

  • GET ä. Proposed use of thalidomide for the cytokine storm of COVID-19 Extract
  • GET 2020. Thalidomide combined with low-dose short-term glucocorticoid in the treatment of critical Coronavirus Disease 2019. Extract
GET 2020. Thalidomide-Revisited: Are COVID-19 Patients Going to Be the Latest Victims of Yet Another Theoretical Drug-Repurposing? Extract


PARP inh

  • GET 2020. Repositioning PARP inhibitors for SARS-CoV-2 infection (COVID-19); a new multi-pronged therapy for ARDS? Extract

P selectin block

  • GET 2020. P-selectin blockade in COVID-19-related ARDS. Extract

CD14

  • GET 2020. Targeting innate immunity by blocking CD14: Novel approach to control inflammation and organ dysfunction in COVID-19 illness. Extract


Proteasome inh

  • GET 2020. Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2. Extract
  • GET 2020. The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges. Extract


Endoplasmic reticulum stress

  • GET 2020. Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19. Extract
  • GET 2020. Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management? Extract

Lysosomes, Autophagy, Membranes

  • GET 2020. Widely available lysosome targeting agents should be considered as potential therapy for COVID-19. Extract
  • GET 2020. Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine. Extract
  • GET 2020. Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype? Extract
  • GET 2020. Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection? Extract
  • GET 2020. May we target double membrane vesicles and oxysterol-binding protein to combat SARS-CoV-2 infection? Extract
  • GET 2020. Autophagie - ein Ansatzpunkt fur ein Medikament gegen COVID-19? : Kampf gegen das Coronavirus. Extract
  • GET 2020. Autophagy and SARS-CoV-2 infection: Apossible smart targeting of the autophagy pathway. Extract


Salinomycin

  • GET 2020. Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent. Extract

Arteminisin

  • GET 2020. Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases. Extract

LMWF5A

  • GET 2020. The novel immunomodulatory biologic LMWF5A for pharmacological attenuation of the "cytokine storm" in COVID-19 patients: a hypothesis. Extract

Quarternary ammonium compounds

  • GET 2020. Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19. Extract

Kv1.3 chanels

  • GET 2020. Targeting lymphocyte Kv1.3-channels to suppress cytokine storm in severe COVID-19: Can it be a novel therapeutic strategy? Extract

Exportin-1

  • GET 2020. Exportin 1 inhibition as antiviral therapy. Extract


Quinoxalines

  • GET 2020. Quinoxaline Derivatives as Antiviral Agents: A Systematic Review. Extract

Pirfenidone

  • GET 2020. Pirfenidone: A novel hypothetical treatment for COVID-19. Extract
  • GET 2020. The added value of pirfenidone to fight inflammation and fibrotic state induced by SARS-CoV-2 : Anti-inflammatory and anti-fibrotic therapy could solve the lung complications of the infection? Extract
  • GET 2020. Effective block by pirfenidone, an antifibrotic pyridone compound (5-methyl-1-phenylpyridin-2[H-1]-one), on hyperpolarization-activated cation current: An additional but distinctive target. Extract


IL-15

  • GET 2020. IL-15 immunotherapy is a viable strategy for COVID-19. Extract


Galectin-3

  • GET 2020. A potential role for Galectin-3 inhibitors in the treatment of COVID-19. Extract

Febuxostat

  • GET 2020. Febuxostat therapy in outpatients with suspected COVID-19: A clinical trial. Extract

Auranofin

  • GET 2020. A Role for Metal-Based Drugs in Fighting COVID-19 Infection? The Case of Auranofin. Extract

Triiodthyronine

  • GET 2020. Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial. Extract

Berberine

Oseltamivir

  • GET 2020. Oseltamivir for coronavirus illness: post-hoc exploratory analysis of an open-label, pragmatic, randomised controlled trial in European primary care from 2016 to 2018. Extract


Glycyrrhizin

  • GET ä. Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19 Extract
GET 2020. Glycyrrhizic-Acid-Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms Extract
  • GET 2020. Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in nonhospitalized COVID-19 patients. Extract
  • GET 2020. Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome? Extract
  • GET 2020. Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection? Extract
  • GET 2020. The comparison of the effectiveness of lincocin(R) and azitro(R) in the treatment of covid-19-associated pneumonia: A prospective study. Extract

Immune checkpoint inhibitors pd1

  • GET 2020. Immune checkpoint inhibitors: a physiology-driven approach to the treatment of coronavirus disease 2019. Extract

Norovir

  • GET 2020. Effects of Gene-Eden-VIR and Novirin on SARS-CoV: Implications for COVID-19. Extract

Spironolactone

  • GET 2020. Can spironolactone be used to prevent COVID-19-induced acute respiratory distress syndrome in patients with hypertension? Extract
  • GET 2020. Use of Spironolactone in SARS-CoV-2 ARDS Patients. Extract
  • GET 2020. Blocking mineralocorticoid receptor with spironolactone may have a wide range of therapeutic actions in severe COVID-19 disease. Extract

Catecholamines

  • GET 2020. Noradrenergic and serotonergic drugs may have opposing effects on COVID-19 cytokine storm and associated psychological effects. Extract


beta adrenergic antagonists

  • GET 2020. Can beta-adrenergic blockers be used in the treatment of COVID-19? Extract

alpha1 adrenergic antagonists

  • GET 2020. Preventing cytokine storm syndrome in COVID-19 using alpha-1 adrenergic receptor antagonists Extract
  • GET ä. What does androgenetic alopecia have to do with COVID?19? An insight into a potential new therapy Extract



Iodine

  • GET 2020. Iodine, a preventive and curative agent in the COVID-19 pandemic? Extract

Bisphosphonates

  • GET 2020. Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection. Extract
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