Target binding and uptake

coviki.org collects the really good Ideas and the scientific Record on Covid-19 Virus.

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32199615 ä. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
32081428 2020. Structure analysis of the receptor binding of 2019-nCoV
32142651 2020. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
32203189 ä. Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine
32047258 ä. Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
32265513 ä. SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion

ACE2
32275855 ä. Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
32279908 ä. Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?
32251718 2020. ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia
32201080 ä. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
32305506 ä. Renin-angiotensin system at the heart of COVID-19 pandemic
32291076 ä. EZH2-mediated H3K27me3 inhibits ACE2 expression
32299780 2020. Angiotensin-Converting Enzyme 2 as the Molecular Bridge Between Epidemiologic and Clinical Features of COVID-19
32299779 ä. What is the Role of Angiotensin Converting Enzyme 2 (ACE2) in COVID-19 Infection in Hypertensive, Diabetic Patients?
32227090 ä. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2
32301968 ä. Binding of SARS-CoV-2 and angiotensin-converting enzyme 2: clinical implications
32133153 2020. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations
32313207 ä. Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor
32264791 2020. Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2

tmprss2

others'

32130973 2020. A potential role for integrins in host cell entry by SARS-CoV-2
32272173 2020. Coronavirus membrane fusion mechanism offers a potential target for antiviral development

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32220422 2020. The hosts angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections
32336612 ä. The pivotal link between ACE2 deficiency and SARS-CoV-2 infection
32210742 2020. Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis
32327200 ä. Covid-19 and the angiotensin-converting enzyme (ACE2): Areas for research

32344526 2020. COVID-19 and RAS: Unravelling an Unclear Relationship
32274964 2020. A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

32169481 2020. COVID-19 spike-host cell receptor GRP78 binding site prediction

32092392 2020. Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV

31996437 2020. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

31826992 2020. Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

antibodies target one serotype of viruses but only subneutralize another, leading to antibody-dependend enhancement of the latter viruses.

32199943 ä. Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2

32362314 ä. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

32221306 2020. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
32094589 ä. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

32372801 2020. (ACE2) Does a cell protein explain covid-19 severity?
32302706 2020. Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

32150576 2020. Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry

32165541 2020. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
32364961 2020. Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
32245784 2020. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
32366695 ä. Site-specific glycan analysis of the SARS-CoV-2 spike
32132184 2020. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
32198713 ä. A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility
32354022 2020. ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?
32365751 2020. The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor

32369402 2020. ANNALS EXPRESS: Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: a closer look at angiotensin-converting enzyme 2 (ACE2)
32378705 2020. A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivity
32132669 2020. Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV
32149770 2020. High-throughput sequencing for confirmation of suspected 2019-nCoV infection identified by fluorescence quantitative polymerase chain reaction