Target binding and uptake

Version vom 12. Juni 2020, 17:53 Uhr

coviki.org collects the really good Ideas and the scientific Record on Covid-19 Virus.

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32199615 ä. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
32081428 2020. Structure analysis of the receptor binding of 2019-nCoV
32142651 2020. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
32203189 ä. Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine
32047258 ä. Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
32265513 ä. SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion

ACE2
32275855 ä. Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
32279908 ä. Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?
32251718 2020. ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia
32201080 ä. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
32305506 ä. Renin-angiotensin system at the heart of COVID-19 pandemic
32291076 ä. EZH2-mediated H3K27me3 inhibits ACE2 expression
32299780 2020. Angiotensin-Converting Enzyme 2 as the Molecular Bridge Between Epidemiologic and Clinical Features of COVID-19
32299779 ä. What is the Role of Angiotensin Converting Enzyme 2 (ACE2) in COVID-19 Infection in Hypertensive, Diabetic Patients?
32227090 ä. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2
32301968 ä. Binding of SARS-CoV-2 and angiotensin-converting enzyme 2: clinical implications
32133153 2020. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations
32313207 ä. Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor
32264791 2020. Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2

tmprss2

others'

32130973 2020. A potential role for integrins in host cell entry by SARS-CoV-2
32272173 2020. Coronavirus membrane fusion mechanism offers a potential target for antiviral development

32220422 2020. The hosts angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections
32336612 ä. The pivotal link between ACE2 deficiency and SARS-CoV-2 infection
32210742 2020. Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis
32327200 ä. Covid-19 and the angiotensin-converting enzyme (ACE2): Areas for research

32344526 2020. COVID-19 and RAS: Unravelling an Unclear Relationship
32274964 2020. A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

32092392 2020. Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV

31996437 2020. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

32199943 ä. Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2

32221306 2020. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
32094589 ä. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

32372801 2020. (ACE2) Does a cell protein explain covid-19 severity?
32302706 2020. Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

32165541 2020. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
32364961 2020. Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
32245784 2020. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
32366695 ä. Site-specific glycan analysis of the SARS-CoV-2 spike
32132184 2020. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
32198713 ä. A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility
32354022 2020. ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?
32365751 2020. The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor

32369402 2020. ANNALS EXPRESS: Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: a closer look at angiotensin-converting enzyme 2 (ACE2)
32378705 2020. A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivity
32132669 2020. Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV
32149770 2020. High-throughput sequencing for confirmation of suspected 2019-nCoV infection identified by fluorescence quantitative polymerase chain reaction

32338224 2020. Focus on Receptors for Coronaviruses with Special Reference to Angiotensin-converting Enzyme 2 as a Potential Drug Target - A Perspective
32306452 2020. Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: A double-edged sword?
32363391 ä. Deducing the N- and O- glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2

32376714 2020. Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein
32100877 ä. Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS?CoV?2
32249956 ä. Structural variations in human ACE2 may influence its binding with SARS?CoV?2 spike protein
32246503 ä. SARS?COV?2 and infectivity: Possible increase in infectivity associated to integrin motif expression
32374430 2020. DC/L-SIGNs of Hope in the COVID-19 Pandemic
32374452 2020. SARS-CoV-2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein
32239522 ä. SARS?CoV?2 spike protein favors ACE2 from Bovidae and Cricetidae

32225176 2020. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
32225175 2020. Structural basis of receptor recognition by SARS-CoV-2

32329276 2020. Spike protein in the detection and treatment of novel coronavirus

32451080 ä. A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization
32047128 2020. Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection
C7190498 ä. The biological characteristics of SARS-CoV-2 spike protein Pro330-Leu650
32329083 2020. (ang.)COVID-19 transmission through host cell directed network of GPCR