Candidate Compounds Covid19

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  '''CHERRYPICKING STUDIES IS NOT SCIENCE
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{{qt|Reviews on covid drug development}}
  
  
'''reviews candidate compounds covid19'''
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*'''[[scouting ideas]]'''
{{tp|p=32226821|t=2020. Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases |pdf=|usr=}}
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{{tp|p=32292689|t=ä. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods |pdf=|usr=}}
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{{tp|p=32318328|t=ä. D3Targets-2019-nCoV: a webserver for predicting drug targets and for multi-target and multi-site based virtual screening against COVID-19 |pdf=|usr=}}
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{{tp|p=32152082|t=2020. Compounds with Therapeutic Potential against Novel Respiratory 2019 Coronavirus |pdf=|usr=}}
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{{tp|p=32232214|t=2020. Potential Treatments for COVID-19; a Narrative Literature Review |pdf=|usr=}}
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{{tp|p=32134278|t=2020. Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19) |pdf=|usr=}}
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{{tp|p=32375268|t=2020. Coronavirus Pandemic-Therapy and Vaccines |pdf=|usr=}}
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{{tp|p=31996494|t=2020. Drug treatment options for the 2019-new coronavirus (2019-nCoV) |pdf=|usr=}}
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{{tp|p=32334062|t=ä. Current status of potential therapeutic candidates for the COVID-19 crisis |pdf=|usr=}}
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{{tp|p=32347359|t=ä. Seeking and destroying the evils from the inside-translating cancer immunity to fight COVID-19 |pdf=|usr=}}
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'''Arbidol''' retarget influenza
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*'''[[PHA Biologicals]]'''
{{tp|p=32373347|t=2020. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro |pdf=|usr=}}
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'''Macrolide antibiotics'''
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*'''[[PHA conventional pharmacology]]'''
{{tp|p=32249257|t=2020. Macrolide treatment for COVID-19: Will this be the way forward?|pdf=|usr=}}
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'''Oleoylethanolamide'''
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*'''[[PHA retargeted compounds]]'''
{{tp|p=32327293|t=ä. Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19 |pdf=|usr=}}
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'''Metronidazole''' retarget
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*'''[[PHA antivirals by mechanism]]'''
{{tp|p=32259129|t=2020. Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen |pdf=|usr=}}
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'''Glutathione GSH''' antioxidant
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*'''[[PHA pharmacophore by screened target]]'''
*[https://nypost.com/2020/05/09/new-york-mom-with-coronavirus-saved-by-medical-student-son/ found in a forrest gump mode]
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*[https://www.sciencedirect.com/science/article/pii/S2213007120301350 Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases]
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'''Chlorpromazine''' retarget
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*'''[[PHA ImmunoNutrients]]
*[https://www.biorxiv.org/content/10.1101/2020.05.05.079608v1 paper]
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'''Zinc''' add-on
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*'''[[PHA compl altern natural]]'''
*[https://www.sciencedirect.com/science/article/pii/S0306987720306435 call for trial]
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'''Selenium'''
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*'''[[PHA within indications compounds]]'''
{{tp|p=32342979|t=ä. Association between regional selenium status and reported outcome of COVID-19 cases in China |pdf=|usr=}}
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'''Remdesivir''' retarget
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*'''[[PHA Serum products]]'''
*[https://gab.com/Remnant601/posts/104122987152232660 one hospital on...]
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{{tp|p=32283108|t=ä. Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites |pdf=|usr=}}
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'''Lauric acid''' nat. compd.
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*'''[[PHA Vaccination]]'''
*[https://www.icp.org.ph/2020/01/the-potential-of-coconut-oil-and-its-derivatives-as-effective-and-safe-antiviral-agents-against-the-novel-coronavirus-ncov-2019/ call for trial]
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'''Nicotine''' nat. toxin
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PHA related options:
*[https://www.usatoday.com/story/news/factcheck/2020/05/03/covid-19-fact-check-caution-urged-study-virus-smoking/3055378001/ france]
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'''Niclosamide'''
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*[[Radiation therapy]]
{{tp|p=32125140|t=ä. Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential |pdf=|usr=}}
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*[[Phototherapy]]
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*[[Electric fields]]
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*[[Treatment other concepts]]
  
'''Microbiome as target'''
 
{{tp|p=32356654|t=ä. Considering the Effects of Microbiome and Diet on SARS-CoV-2 Infection: Nanotechnology Roles |pdf=|usr=}}
 
  
'''ACE2 as target'''
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A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea.
{{tp|p=32286790|t=ä. Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2 |pdf=|usr=}}
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This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world
{{tp|p=32333836|t=ä. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 |pdf=|usr=}}
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vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents.
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Paper is (not yet in PubMed) :
  
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*'''[https://www.sciencedirect.com/science/article/pii/S1097276520305499?via%3Dihub Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication at Mol Cell 2020/08/11]'''
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credentials to [https://web.de/magazine/news/coronavirus/coronavirus-blockade-zellulaerer-kommunikation-forscher-stoppen-vermehrung-sars-cov-2-35045170 Marinus Brandl] who told us about it today.
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based on e.g.
  
'''Garlic extracts'''
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{{ttp|p=32408336|t=2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets |pdf=|usr=}}
{{tp|p=32363255|t=ä. Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil |pdf=|usr=}}
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'''Dipyridamole''' retarget
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=======================================================================================
{{tp|p=32318327|t=ä. Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19 |pdf=|usr=}}
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'''stem cells'''
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  COVID19 is now a CURABLE disease !!!
{{tp|p=32257554|t=2020. Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia |pdf=|usr=}}
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{{tp|p=32257537|t=2020. Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia |pdf=|usr=}}
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'''Ivermectin'''
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  =======================================================================================
{{tp|p=32330482|t=ä. Ivermectin and COVID-19: a report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors  responses |pdf=|usr=}}
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'''Various Leads'''
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*[https://theconversation.com/we-found-and-tested-47-old-drugs-that-might-treat-the-coronavirus-results-show-promising-leads-and-a-whole-new-way-to-fight-covid-19-136789 9 retargeted: ternatin4, zotatifin, plitidepsin; haloperidol, melperone, clemastine, cloperastine, pb28, progesterone]
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*[https://doi.org/10.1038/s41586-020-2286-9 paper in nature]
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{{tp|p=32251767|t=2020. Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro |pdf=|usr=}}
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'''Interferons'''
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{{tp|p=32275914|t=2020. Type 1 interferons as a potential treatment against COVID-19 |pdf=|usr=}}
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{{tp|p=32360182|t=2020. Antiviral activities of type I interferons to SARS-CoV-2 infection |pdf=|usr=}}
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'''Therapeutic antibodies (virus-targeted)'''
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*[https://www.foxnews.com/science/man-made-antibody-neutralizes-coronavirus-first-time anti covid mab]
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*[https://www.telegraaf.nl/nieuws/750205601/nederlands-antilichaam-47-d11-blokkeert-infectie-coronavirus acmab 47d11]
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{{tp|p=32375025|t=ä. Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain  Camelid Antibodies |pdf=|usr=}}
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'''Therapeutic antibodies and biologicals (cytokine/sugnal transduction)'''
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{{tp|p=32247642|t=ä. Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report |pdf=|usr=}}
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{{tp|p=32241793|t=2020. Clinical course of COVID-19 in a series of patients with chronic arthritis treated with immunosuppressive targeted therapies |pdf=|usr=}}
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{{tp|p=32243501|t=2020. First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab |pdf=|usr=}}
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'''CRISPR genome editing technology'''
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{{tp|p=32353252|t=ä. Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza |pdf=|usr=}}
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'''Other antirheumatic compounds'''
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''Hydroxy-Chloroquine''
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*check retina status; monitor rhythm known toxicity
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*[https://justthenews.com/politics-policy/coronavirus/doctors-find-hydroxychloroquin-success-rate-91-urge-arizona-maybe-make 91% benefit]
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*[https://www.themoscowtimes.com/2020/04/17/russia-approves-unproven-malaria-drug-to-treat-coronavirus-a70025 approval russia]
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*[https://m.timesofindia.com/business/india-business/covid-19-68-new-companies-get-fdca-permit-to-make-hcq/amp_articleshow/75566317.cms scale up production]
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*[https://www.medrxiv.org/content/10.1101/2020.04.26.20081059v1.full.pdf+html on safety, trial]
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*[https://www.nejm.org/doi/full/10.1056/NEJMoa2012410?query=C19&cid=DM91569_NEJM_Registered_Users_and_InActive&bid=193180241 Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19] ''substance is useless.''
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{{tp|p=32232419|t=ä. Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know |pdf=|usr=}}
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{{tp|p=32227189|t=ä. A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19 |pdf=|usr=}}
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{{tp|p=32147496|t=2020. Of chloroquine and COVID-19 |pdf=|usr=}}
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{{tp|p=32074550|t=2020. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies |pdf=|usr=}}
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{{tp|p=32321905|t=2020. Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database |pdf=|usr=}}
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{{tp|p=32281583|t=2020. Update on use of chloroquine/hydroxychloroquine to treat coronavirus disease 2019 (COVID-19) |pdf=|usr=}}
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{{tp|p=32265182|t=2020. Should chloroquine and hydroxychloroquine be used to treat COVID-19? A rapid review |pdf=|usr=}}
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'''Chemoprevention Covid19'''
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'''Antiviral agents Covid19'''
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'''Lung regeneration and repair after Covid19'''
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'''resilience enhancement'''
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{{tp|p=32229705|t=2020. Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections |pdf=|usr=}}
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{{tp|p=32311498|t=ä. The impact of nutrition on COVID-19 susceptibility and long-term consequences |pdf=|usr=}}
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'''psychoneuroimmunology'''
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{{tp|p=32234338|t=ä. Using psychoneuroimmunity against COVID-19 |pdf=|usr=}}
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'''cannabinoids'''
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{{tp|p=32360437|t=ä. SARS-CoV2 induced respiratory distress: Can cannabinoids be added to anti-viral therapies to reduce lung inflammation?|pdf=|usr=}}
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'''Complementary & Traditional chinese medicine & Ethnopharm'''
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{{tp|p=32245701|t=ä. Is traditional Chinese medicine useful in the treatment of COVID-19?|pdf=|usr=}}
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{{tp|p=32233641|t=2020. Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19 |pdf=|usr=}}
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*[https://www.aa.com.tr/en/africa/madagascar-slams-who-for-not-endorsing-its-herbal-cure/1836905 madagascar herbs]
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{{tp|p=32229706|t=2020. COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?|pdf=|usr=}}
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{{tp|p=32037389|t=2020. Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment |pdf=|usr=}}
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{{tp|p=32334064|t=ä. Ayurveda and COVID-19: where psychoneuroimmunology and the meaning response meet |pdf=|usr=}}
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'''Exercise'''
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{{tp|p=32311497|t=ä. The immunological case for staying active during the COVID-19 pandemic |pdf=|usr=}}
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'''Topical agents''' opening up the world of nano...
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*[https://www.dailymail.co.uk/sciencetech/article-8315269/Commercial-mouthwash-prevent-COVID-19-transmission-scientists-say.html on mouth rinses]
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'''Anticoagulants'''
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*[[Anticoagulant in covid19]]
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'''Vaccination Covid19'''
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{{tp|p=32105090|t=2020. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic |pdf=|usr=}}
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*[https://patch.com/massachusetts/cambridge/ma-company-takes-critical-step-toward-covid-19-vaccine mrna-1273, moderna]
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Aktuelle Version vom 21. September 2021, 06:15 Uhr

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hottest actual papers
 P further streaming-in related content is here
 CHERRYPICKING STUDIES IS NOT SCIENCE
Reviews on covid drug development


PHA related options:


A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea.
This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world
vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents.
Paper is (not yet in PubMed) :

credentials to Marinus Brandl who told us about it today. based on e.g.

32408336 2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets
=======================================================================================
COVID19 is now a CURABLE disease !!!
=======================================================================================

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