Magnesium Cobalt als Mediator

Sowohl TRPM7 als auch SLC41A1 sind unselektive Kationentransporter. Somit kann jedes Kation als Toxin interpretiert werden. Cobaltchlorid führt ...zur zellulären Hypoxie... VEGF, EPO, Inflammation, Neoangiogenese.

Die Biblio hier zeigt zunächst Kobalt X HIFalpha mit kurzen Suchtermen nur in PubMed.

31867478 2019. Molecular and Cellular Response of Co-cultured Cells toward Cobalt Chloride (CoCl2)-Induced Hypoxia.
26579469 2015. HIF-1alpha pathway: role, regulation and intervention for cancer therapy.
32711072 2021. Mechanisms Leading to Differential Hypoxia-Inducible Factor Signaling in the Diabetic Kidney: Modulation by SGLT2 Inhibitors and Hypoxia Mimetics.
26561638 2016. Activation of aryl hydrocarbon receptor mediates suppression of hypoxia-inducible factor-dependent erythropoietin expression by indoxyl sulfate.
17442736 2007. Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1.
17878221 2007. HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.
15284066 2004. Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling.
21926263 2011. Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.
19915160 2010. Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.
17616644 2007. HIF stabilizing agents: shotgun or scalpel?
17545484 2007. Effect of chemical stabilizers of hypoxia-inducible factors on early lung development.
23467423 2013. miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-alpha activation.
20881034 2010. Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade.
12595275 2003. Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells.
11592948 2001. Transcriptional regulation of heme oxygenases by HIF-1alpha in renal medullary interstitial cells.
33668397 2021. Protective Effects of 6,7,4'-Trihydroxyflavanone on Hypoxia-Induced Neurotoxicity by Enhancement of HO-1 through Nrf2 Signaling Pathway.
31527445 2019. Induction of Redox-Active Gene Expression by CoCl2 Ameliorates Oxidative Stress-Mediated Injury of Murine Auditory Cells.
20508205 2010. Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants.
20131233 2010. Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction.
18050252 2007. Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis.
28244246 2017. Cobalt(II) Chloride Modifies the Phenotype of Macrophage Activation.
8611159 1996. Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin.
31234767 2019. Hypoxia as a Factor Involved in the Regulation of the apoA-1, ABCA1, and Complement C3 Gene Expression in Human Macrophages.
22349312 2012. Overexpression of HIF-1alpha transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats.
32126269 2020. Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles.
19396871 2009. Cobalt-induced oxidant stress in cultured endothelial cells: prevention by ascorbate in relation to HIF-1alpha.
19652374 2009. Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride.
19043209 2008. Establishment of a cell-based assay to screen regulators of the hypoxia-inducible factor-1-dependent vascular endothelial growth factor promoter.
30876462 2019. CoCl2 simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis.
33451366 2021. Bioactive glasses and electrospun composites that release cobalt to stimulate the HIF pathway for wound healing applications.
30681674 2019. A stimuli-responsive drug release nanoplatform for kidney-specific anti-fibrosis treatment.
14525760 2004. Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration.
27439603 2016. Suppression of Akt-HIF-1alpha signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis.
23496980 2013. Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1alpha in hepatocellular carcinoma.
23756865 2013. Inhibition of VEGF expression through blockade of Hif1alpha and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
25625917 2015. The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia.
22831549 2012. Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1alpha.
23947803 2013. HIF-1alpha/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs).
24403227 2013. BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
11358837 2001. Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.
10910041 2000. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism.
24788415 2014. Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory responsedagger.
15271983 2004. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.
12606543 2003. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.
11356853 2001. Cobalt induces heme oxygenase-1 expression by a hypoxia-inducible factor-independent mechanism in Chinese hamster ovary cells: regulation by Nrf2 and MafG transcription factors.
10833514 2000. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
10085152 1999. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling.
10207038 1999. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation.
9235919 1997. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension.
7836384 1995. Purification and characterization of hypoxia-inducible factor 1.
8537383 1995. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells.
8089148 1994. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
8308005 1994. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
25952107 2015. Tetramethylpyrazine inhibits CoCl2 -induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1alpha/NOX2/ROS pathways.
23065176 2013. Radioprotective effect on HepG2 cells of low concentrations of cobalt chloride: induction of hypoxia-inducible factor-1 alpha and clearance of reactive oxygen species.
33015417 2020. Mutual Antagonism of Hypoxia-Inducible Factor Isoforms in Cardiac, Vascular, and Renal Disorders.
30977589 2019. Protective effects of HO-1 pathway on lung injury subsequent to limb ischemia reperfusion.
16316346 2005. Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis.
9027736 1997. Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors.
22707888 2012. Phosphodiesterase inhibitor improves renal tubulointerstitial hypoxia of the diabetic rat kidney.
24436242 2015. Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
17967866 2008. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.
12123724 2002. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
33491566 2021. Nrf2 mediates hypoxia-inducible HIF1alpha activation in kidney tubular epithelial cells.
15256383 2004. Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism.
28249915 2017. Cobalt Chloride-induced Hypoxia Induces Epithelial-mesenchymal Transition in Renal Carcinoma Cell Lines.
32885420 2020. Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals.
17627474 2007. Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.
30205954 2018. Indoxyl glucuronide, a protein-bound uremic toxin, inhibits hypoxia-inducible factordependent erythropoietin expression through activation of aryl hydrocarbon receptor.
26826385 2016. Cobalt chloride-mediated protein kinase Calpha (PKCalpha) phosphorylation induces hypoxia-inducible factor 1alpha (HIF1alpha) in the nucleus of gastric cancer cell.
25824035 2015. HO-1 expression control in the rat glomerulus.
22424098 2012. PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress.
15147973 2004. Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1alpha (HIF-1alpha): structural requirement of bisphenol A for degradation of HIF-1alpha.
12810083 2003. pVHL-independent ubiquitination of HIF1alpha and its stabilization by cobalt ion.
12670503 2003. Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells.
12099689 2002. HIF-1alpha-prolyl hydroxylase: molecular target of nitric oxide in the hypoxic signal transduction pathway.
10814519 2000. Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells.
28012960 2017. Heme oxygenase (HO)-1 induction prevents Endoplasmic Reticulum stress-mediated endothelial cell death and impaired angiogenic capacity.
15865434 2005. Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.
14726713 2004. HIF-1: an oxygen and metal responsive transcription factor.
23142284 2013. Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells.
33200474 2021. Hypoxia-induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3beta pathway.
32239594 2020. Plantamajoside inhibits the proliferation and epithelial-to-mesenchymal transition in hepatocellular carcinoma cells via modulating hypoxia-inducible factor-1alpha-dependent gene expression.
25339500 2015. HGF expression induced by HIF-1alpha promote the proliferation and tube formation of endothelial progenitor cells.
7528597 1994. Hypoxia regulatory elements of the human vascular endothelial growth factor gene.
21617913 2012. HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells.
24486403 2014. NF-kappaB enhances hypoxia-driven T-cell immunosuppression via upregulation of adenosine A(2A) receptors.
26211648 2015. Attenuation of Magnesium Sulfate on CoCl(2)-Induced Cell Death by Activating ERK1/2/MAPK and Inhibiting HIF-1alpha via Mitochondrial Apoptotic Signaling Suppression in a Neuronal Cell Line.
12114320 2002. Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein Shc in endothelial cells.
29223764 2019. Hypoxia-induced and HIF1alpha-VEGF-mediated tight junction dysfunction in choriocarcinoma cells: Implications for preeclampsia.
10919714 1999. Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line.
26715508 2016. NF-kappaB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury.
24256203 2014. Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption.
33838581 2021. Exosomes derived from macrophages upon cobalt ion stimulation promote angiogenesis.
18473772 2008. Hypoxia inducible factor-1 alpha, endothelial progenitor cells, monocytes, cardiovascular risk, wound healing, cobalt and hydralazine: a unifying hypothesis.
34428999 2021. Inhibition of hypoxia-inducible factor-1 by Salidroside in an in vitro model of choroidal neovascularization.
21514683 2011. Effect of pioglitazone on diabetic nephropathy and expression of HIF-1alpha and VEGF in the renal tissues of type 2 diabetic rats.
22340517 2013. Hypoxia suppresses E-cadherin and enhances matrix metalloproteinase-2 expression favoring esophageal carcinoma migration and invasion via hypoxia inducible factor-1 alpha activation.
27297870 2017. Andrographolide inhibits hypoxia-induced HIF-1alpha-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells.
26688571 2016. alpha-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1alpha and STAT3 signaling pathways.
21296072 2011. Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat.
19374849 2009. The redox state of glutathione regulates the hypoxic induction of HIF-1.
28185835 2017. Requirement of Hsp105 in CoCl2-induced HIF-1alpha accumulation and transcriptional activation.
18255061 2008. Hypoxia modulates lipopolysaccharide induced TNF-alpha expression in murine macrophages.
34143536 2021. Leptin attenuates hypoxia-induced apoptosis in human periodontal ligament cells via the reactive oxygen species-hypoxia-inducible factor-1alpha pathway.
19007879 2009. Hypoxia-inducible factor 1 alpha under rapid enzymatic hypoxia: cells sense decrements of oxygen but not hypoxia per se.
21480981 2012. Delayed myocardial preconditioning induced by cobalt chloride in the rat: HIF-1alpha and iNOS involvement.
19278353 2009. Hypoxic preconditioning with cobalt attenuates hypobaric hypoxia-induced oxidative damage in rat lungs.
18331222 2008. Cobalt supplementation promotes hypoxic tolerance and facilitates acclimatization to hypobaric hypoxia in rat brain.
21256160 2011. Induction of heme oxygenase-1 expression by cilostazol contributes to its anti-inflammatory effects in J774 murine macrophages.
18708157 2009. Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures.
33907819 2021. Naringin protects H9C2 cardiomyocytes from chemical hypoxiainduced injury by promoting the autophagic flux via the activation of the HIF1alpha/BNIP3 signaling pathway.
17403894 2007. The ternary complex factor net is downregulated by hypoxia and regulates hypoxia-responsive genes.
12242281 2002. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.
12370288 2002. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.
10340472 1999. Aromatic hydrocarbon nuclear translocator as a common component for the hypoxia- and dioxin-induced gene expression.
30628711 2019. Effects of nuclear respiratory factor1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells.
27220406 2016. Notch signaling represses hypoxia-inducible factor-1alpha-induced activation of Wnt/beta-catenin signaling in osteoblasts under cobalt-mimicked hypoxia.
27499609 2016. Tissue factor induces VEGF expression via activation of the Wnt/beta-catenin signaling pathway in ARPE-19 cells.
27527871 2016. Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury.
34136065 2021. Hypoxia Induced by Cobalt Chloride Triggers Autophagic Apoptosis of Human and Mouse Drug-Resistant Glioblastoma Cells through Targeting the PI3K-AKT-mTOR Signaling Pathway.
31533843 2019. HIF-1alpha is a key mediator of the lung inflammatory potential of lithium-ion battery particles.
23942037 2013. Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.
29263117 2017. Stabilization of hypoxia inducible factor by cobalt chloride can alter renal epithelial transport.
28420760 2017. Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia.
31600313 2019. Hypoxia induction in cultured pancreatic islets enhances endothelial cell morphology and survival while maintaining beta-cell function.
25978439 2015. Hypoxia-induced retinal neovascularization in zebrafish embryos: a potential model of retinopathy of prematurity.
25051011 2014. TNF-alpha mediated increase of HIF-1alpha inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).
24614111 2014. Upregulated copper transporters in hypoxia-induced pulmonary hypertension.
24497960 2014. Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination.
24386269 2013. Exposure to cobalt causes transcriptomic and proteomic changes in two rat liver derived cell lines.
24349374 2013. Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection.
24098539 2013. Autophagy induced by HIF1alpha overexpression supports trophoblast invasion by supplying cellular energy.
23840602 2013. Cobalt-alloy implant debris induce HIF-1alpha hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure.
23469202 2013. Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1alpha and proteasome-mediated pathways.
23145036 2012. Hypoxia-inducible factor activation protects the kidney from gentamicin-induced acute injury.
23133644 2012. HIF-1alpha inhibition reduces nasal inflammation in a murine allergic rhinitis model.
19587783 2009. Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells.
11504942 2001. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.
9751731 1998. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.
9636155 1998. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia.
7538678 1995. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells.
30277425 2018. The long non-coding RNA MALAT1 is increased in renal ischemia-reperfusion injury and inhibits hypoxia-induced inflammation.
26325091 2015. Induction of VEGFA mRNA translation by CoCl2 mediated by HuR.
28374767 2017. Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
26174737 2015. Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition.
32670550 2020. beta-Escin alleviates cobalt chloride-induced hypoxia-mediated apoptotic resistance and invasion via ROS-dependent HIF-1alpha/TGF-beta/MMPs in A549 cells.
24218148 2014. Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.
20511350 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.
19502547 2009. Identification of chemical compounds that induce HIF-1alpha activity.
28737660 2017. Renal Protection Mediated by Hypoxia Inducible Factor-1alpha Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1.
25171655 2014. Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network.
23704825 2013. Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation.
16596228 2006. Noscapine inhibits hypoxia-mediated HIF-1alpha expression andangiogenesis in vitro: a novel function for an old drug.
30484873 2019. The use of cobalt chloride as a chemical hypoxia model.
29254287 2017. Thymoquinone protects against cobalt chloride-induced neurotoxicity via Nrf2/GCL-regulated glutathione homeostasis.
30508321 2019. Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts.
30387200 2018. Stabilization of hypoxia-inducible factor 1alpha by cobalt chloride impairs podocyte morphology and slit-diaphragm function.
20232316 2010. miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.
11739637 2001. A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses.
26730678 2016. Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo.
18026918 2007. Hypoxia and the HIF system in kidney disease.
28639376 2018. mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways.
32462687 2021. Effects of cobalt and chromium ions on glycolytic flux and the stabilization of hypoxia-inducible factor-1alpha in macrophages in vitro.
22619252 2012. Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1.
31267382 2019. Impact of different methods of induction of cellular hypoxia: focus on protein homeostasis signaling pathways and morphology of C2C12 skeletal muscle cells differentiated into myotubes.
32621152 2021. Transcriptomic analysis reveals the role of a peptide derived from CRYAB on the CoCl2-induced hypoxic HL-1 cardiomyocytes.
21863063 2011. Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner.
16127428 2005. Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model.
23478664 2013. The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis.
33275989 2021. Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis.
16050983 2005. Adaptive responses to mitochondrial dysfunction in the rho degrees Namalwa cell.
32529496 2020. Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells.
11043581 2000. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha.
18462799 2008. HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6.
26676934 2016. Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1alpha-VEGF pathway.
9804609 1998. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity.
25676618 2015. Importance of the HIF pathway in cobalt nanoparticle-induced cytotoxicity and inflammation in human macrophages.
10353251 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
9537326 1998. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha.
29474875 2018. Rig-I is involved in inflammation through the IPS-1/TRAF(6) pathway in astrocytes under chemical hypoxia.
26518240 2016. VEGF-mediated NF-kappaB activation protects PC12 cells from damage induced by hypoxia.
23916558 2013. The role of HIF in cobalt-induced ischemic tolerance.
19384570 2009. Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells.
15592522 2005. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.
24100543 2013. Hypoxia-induced overexpression of DEC1 is regulated by HIF-1alpha in hepatocellular carcinoma.
20523104 2010. Isolation and characterization of fetus human retinal microvascular endothelial cells.
22487528 2012. Hypoxia-inducible factor-1 up-regulates the expression of Toll-like receptor 4 in pancreatic cancer cells under hypoxic conditions.
19285840 2009. Hypoxia-HIF-1alpha-C/EBPalpha/Runx1 signaling in leukemic cell differentiation.
9049173 1997. Hypoxia and cobalt stimulate vascular endothelial growth factor receptor gene expression in rats.
8927508 1996. Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo.
19191011 2009. Highly efficient transfection of rat cortical neurons using carbosilane dendrimers unveils a neuroprotective role for HIF-1alpha in early chemical hypoxia-mediated neurotoxicity.
30808828 2019. Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis.
30448832 2019. Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro.
19478549 2009. Effects of lipoxin A(4) on CoCl(2)-induced angiogenesis and its possible mechanisms in human umbilical vein endothelial cells.
27244052 2016. Light-Emitting Diode Irradiation (640 nm) Regulates Keratinocyte Migration and Cytoskeletal Reorganization Via Hypoxia-Inducible Factor-1alpha.
11978060 2002. Mechanisms of oxygen sensing in human trophoblast cells.
23138928 2013. Negative regulation of NEP expression by hypoxia.
16622835 2006. Comparative proteomic analysis of hypoxia-treated and untreated human leukemic U937 cells.
27756181 2016. Silencing HIF-1alpha aggravates growth inhibition and necrosis of proximal renal tubular epithelial cell under hypoxia.
26850547 2016. Towards the elimination of excessive cobalt supplementation in racing horses: A pharmacological review.
22732165 2012. Cobalt metabolism and toxicology--a brief update.
11292862 2001. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
21412184 2011. Hypoxia-inducible factor 1alpha regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
32799744 2020. Hypoxia Protects Rat Bone Marrow Mesenchymal Stem Cells Against Compression-Induced Apoptosis in the Degenerative Disc Microenvironment Through Activation of the HIF-1alpha/YAP Signaling Pathway.
21293012 2011. NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.
29417848 2018. Triiodothyronine stimulates VEGF expression and secretion via steroids and HIF-1alpha in murine Leydig cells.
24328340 2014. Role of oxygen in the regulation of Leydig tumor derived MA-10 cell steroid production: the effect of cobalt chloride.
32835935 2020. HIF-1alpha induces hypoxic apoptosis of MLO-Y4 osteocytes via JNK/caspase-3 pathway and the apoptotic-osteocyte-mediated osteoclastogenesis in vitro.
30849457 2019. Comparison of the neurotoxicity associated with cobalt nanoparticles and cobalt chloride in Wistar rats.
29966676 2018. Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
25617811 2015. Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor.
22982409 2012. Augmentation of aerobic respiration and mitochondrial biogenesis in skeletal muscle by hypoxia preconditioning with cobalt chloride.
18635243 2008. Cobalt chloride attenuates hypobaric hypoxia induced vascular leakage in rat brain: molecular mechanisms of action of cobalt chloride.
22269387 2012. Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1alpha pathway.
32534005 2020. Roxadustat attenuates experimental pulmonary fibrosis in vitro and in vivo.
23788631 2013. Metal allergens induce nitric oxide production by mouse dermal fibroblasts via the hypoxia-inducible factor-2alpha-dependent pathway.
20719750 2010. Cobalt-Induced lung injury and hypoxia-inducible factor 1 alpha.
15375294 2004. The role of hypoxia inducible factor 1alpha in cobalt chloride induced cell death in mouse embryonic fibroblasts.
29355601 2018. Nickel ions bind to HSP90beta and enhance HIF-1alpha-mediated IL-8 expression.
33582245 2021. Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics.
23267795 2013. All-trans retinoic acid protects renal tubular epithelial cells against hypoxia induced injury in vitro.
23746243 2013. [Angiotensin-(1-7) inhibits hypoxia-induced renal tubular epithelial-to-mesenchymal transition in rats].
19549358 2009. [Hypoxia and its simulant CoCl(2) down-regulates Foxp3 expression independent from HIF-1alpha].