drug: Remdesivir, GS-5734;
metabolites: GS-441524, Captisol, GS-704277
prodrug: GS-441524
32223926 2020. Remdesivir attenuates high fat diet (HFD)-induced NAFLD by regulating hepatocyte dyslipidemia and inflammation via the suppression of STING
32283108 ä. Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
32020029 2020. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
32378648 2020. Rapid review for the anti-coronavirus effect of remdesivir
32147516 ä. Arguments in favour of remdesivir for treating SARS-CoV-2 infections
32333086 ä. Remdesivir bei Patienten mit schwerer COVID-19
32361744 ä. Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease
32275812 ä. Compassionate Use of Remdesivir for Patients with Severe Covid-19
32284326 2020. Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
32094225 2020. The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
32258351 2020. Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses
32054787 2020. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
32239125 2020. Remdesivir, la esperanza antiviral frente al SARS-CoV-2
32358203 ä. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
32145386 ä. Remdesivir as a possible therapeutic option for the COVID-19
32247927 ä. Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence
32321732 2020. Remdesivir in covid-19
32357949 2020. Covid-19: Remdesivir is helpful but not a wonder drug, say researchers
32350436 2020. Hopes rise for coronavirus drug remdesivir
32483554 ä. Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
32281114 2020. Delayed Initiation of Remdesivir in a COVID-19-Positive Patient
32401466 2006. Remdesivir
32456606 2020. Synergistic effect of vitamin D and remdesivir can fight COVID-19.
32503874 2020. Efficacy of remdesivir in patients with COVID-19: a protocol for systematic review and meta-analysis of randomised controlled trials.
32458279 2020. Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit.
32396771 2020. Remdesivir in the treatment of coronavirus disease 2019 (COVID-19): a simplified summary.
32397906 2020. Development of remdesivir repositioning as a nucleotide analog against COVID-19 RNA dependent RNA polymerase.
32439198 2020. Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More.
32513665 2020. Remdesivir in Patients with Acute or Chronic Kidney Disease and COVID-19.
32418190 2020. Early experience with remdesivir in SARS-CoV-2 pneumonia.
32521159 2020. Structural Basis of the Potential Binding Mechanism of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase.
32468196 2020. Remdesivir in Treatment of COVID-19: A Systematic Benefit-Risk Assessment.
32515337 2020. [Remdesivir til behandling af COVID-19-pneumoni].
32445440 2020. Remdesivir for the Treatment of Covid-19 - Preliminary Report.
32516797 2020. Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.
32572516 2020. Remdesivir bei Patienten mit COVID-19.
32589775 2020. Safety, Tolerability, and Pharmacokinetics of Remdesivir, an Antiviral for Treatment of COVID-19, in Healthy Subjects.
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32568620 2020. Remdesivir (GS-5734) as a therapeutic option of 2019-nCOV main protease - in silico approach.
32407959 2020. Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post-treatment hospitalisation status.
32412709 2020. Compassionate Use of Remdesivir in Covid-19. Reply.
32412708 2020. Compassionate Use of Remdesivir in Covid-19.
32412707 2020. Compassionate Use of Remdesivir in Covid-19.
32412706 2020. Compassionate Use of Remdesivir in Covid-19.
32412705 2020. Compassionate Use of Remdesivir in Covid-19.
32554811 2020. Infant With SARS-CoV-2 Infection Causing Severe Lung Disease Treated With Remdesivir.
32506110 2020. Use of Remdesivir in the Management of COVID-19: A Systematic Review on Current Evidences.
32459919 2020. Remdesivir for 5 or 10 Days in Patients with Severe Covid-19.
32446287 2020. Remdesivir: Review of pharmacology, pre-clinical data and emerging clinical experience for COVID-19.
32492200 2020. Remdesivir and Tocilizumab: Mix or Match.
32423584 2020. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
32423580 2020. Remdesivir for COVID-19: challenges of underpowered studies
32573468 2020. Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient.
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32607555 2020. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.
32568289 2020. Have we found the panacea to COVID-19 with remdesivir, an old but newly packaged drug?
32595613 2020. Remdesivir (GS-5734) Impedes Enterovirus Replication Through Viral RNA Synthesis Inhibition.
32520466 2020. Remdesivir et Covid-19: resultats negatifs mais methode de recherche (enfin) appropriee !
32574236 2020. Available Evidence and Ongoing Clinical Trials of Remdesivir: Could It Be a Promising Therapeutic Option for COVID-19?
32579980 2020. Validity of the UK Early Access to Medicines Scheme Criteria for Remdesivir use in patients with COVID-19 disease.
32562915 2020. A new pharmacological approach based on remdesivir aerosolized administration on SARS-CoV-2 pulmonary inflammation: A possible and rational therapeutic application.
32594120 2020. Drug-induced liver injury in a COVID-19 patient: potential interaction of remdesivir with P-glycoprotein inhibitors.
32402130 2020. What Do We Know About Remdesivir Drug Interactions?
32405143 2020. Remdesivir - A giant step, or a tiptoe?
32459913 2020. Remdesivir - An Important First Step.
32550880 2020. Recommandations EMA sur l'usage compassionnel du remdesivir.
32579163 2020. Missed Opportunities on Emergency Remdesivir Use.
32618794 2020. Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19).
32619764 2020. Case reports study of the first five patients COVID-19 treated with remdesivir in France.
32649074 2020. Remdesivir for the Treatment of Covid-19 - Preliminary Report.
32649075 2020. Remdesivir for the Treatment of Covid-19 - Preliminary Report.
32649076 2020. Remdesivir for the Treatment of Covid-19 - Preliminary Report.
32649077 2020. Remdesivir for the Treatment of Covid-19 - Preliminary Report.
32649078 2020. Remdesivir for the Treatment of Covid-19 - Preliminary Report. Reply.
32651941 2020. That Escalated Quickly: Remdesivir's Place in Therapy for COVID-19.
32651941 2020. That Escalated Quickly: Remdesivir's Place in Therapy for COVID-19.
32652563 2020. Remdesivir during induction chemotherapy for newly diagnosed paediatric acute lymphoblastic leukaemia with concomitant SARS-CoV-2 infection.
32665225 2020. Covid-19: Experts criticise claim that remdesivir cuts death rates.
32665809 ?. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.
32665809 2020. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.
32668216 2020. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.
32670785 2020. Successful recovery from COVID-19 pneumonia after receiving baricitinib, tocilizumab, and remdesivir. A case report: Review of treatments and clinical role of computed tomography analysis.
32687756 2020. Remdesivir improved time to recovery in adults hospitalized with COVID-19 and lower respiratory tract involvement.
32696862 2020. Use of remdesivir for patients with Covid-19: a review article.
32702095 2020. Persistent COVID-19 in an Immunocompromised Patient Temporarily Responsive to Two Courses of Remdesivir Therapy.
32702590 2020. Intermolecular interaction among Remdesivir, RNA and RNA-dependent RNA polymerase of SARS-CoV-2 analyzed by fragment molecular orbital calculation.
32706859 2020. Remdesivir for Severe COVID-19 versus a Cohort Receiving Standard of Care.
32711596 2020. Interactions Between Remdesivir, Ribavirin, Favipiravir, Galidesivir, Hydroxychloroquine and Chloroquine with Fragment Molecular of the COVID-19 Main Protease with Inhibitor N3 Complex (PDB ID:6LU7) Using Molecular Docking.
32721580 2020. Hepatic Disorders With the Use of Remdesivir for Coronavirus 2019.
32725454 2020. Liver injury in remdesivir-treated COVID-19 patients.
32726230 2020. Remdesivir for the Treatment of COVID-19: A Systematic Review of the Literature.
32726231 2020. Addendum to Systematic Review of Remdesivir for the Treatment of COVID-19.
32732277 2020. Covid-19: Remdesivir probably reduces recovery time, but evidence is uncertain, panel finds.
32732352 2020. Remdesivir for severe covid-19: a clinical practice guideline.
32735655 2020. The Multidimensional Challenge of Treating COVID-19: Remdesivir is a Foot in the Door.
32753375 2020. BET 1: The role of remdesivir in COVID-19 infection.
32757500 2020. Clinical Experience with Use of Remdesivir in the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2: a Case Series.
32763313 2020. Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses.
32771381 2020. Use of remdesivir for pregnant patients with severe novel coronavirus disease 2019.
32773440 2020. A Review of Remdesivir for COVID-19: Data to Date.
32786401 2020. A Chemoenzymatic Synthesis of the (RP)-Isomer of the Antiviral Prodrug Remdesivir.
32792942 2020. Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of I K(M) or I K(DR) and in the Stimulation of I MEP.
32804187 2020. Policy Implications of the Orphan Drug Designation for Remdesivir to Treat COVID-19.
32813283 2020. Effectiveness of remdesivir for the treatment of hospitalized Covid-19 persons: a network meta-analysis.
32827627 2020. Effect of remdesivir on patients with COVID-19: A network meta-analysis of randomized control trials.
32814341 2020. COVID-19 and remdesivir in pediatric patients: the invisible part of the iceberg.
32821086 2020. A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19.
32821882 2020. Metabolic Efficacy of Phosphate Prodrugs and the Remdesivir Paradigm.
32821934 2020. Efficacy of Remdesivir in COVID-19.
32821939 2020. Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial.
32829390 2020. Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU.
32838064 2020. Remdesivir and its antiviral activity against COVID-19: A systematic review.
32861965 2020. Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2.
32863273 2020. Antiviral treatment for COVID-19: the evidence supporting remdesivir.
32864571 2020. Potential Interactions of Remdesivir with Pulmonary Drugs: a Covid-19 Perspective.
32868327 2020. Removal of remdesivir's metabolite GS-441524 by hemodialysis in a double lung transplant recipient with COVID-19.
32870481 2020. Remdesivir: First Approval.
32870563 2020. Catalytic Asymmetric Synthesis of the Anti-COVID-19 Drug Remdesivir.
32874008 2020. Indian perspective of remdesivir: A promising COVID-19 drug.
32882638 2020. Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2.
32896184 2020. Remdesivir, a remedy or a ripple in severe COVID-19?
32909843 2020. Remdesivir emergency approvals: a comparison of the U.S., Japanese, and EU systems.
32921965 2020. Biological, molecular and pharmacological characteristics of chloroquine, hydroxychloroquine, convalescent plasma, and remdesivir for COVID-19 pandemic: A comparative analysis.
32934969 2020. Remdesivir Treatment for Severe COVID-19 in Third-Trimester Pregnancy: Case Report and Management Discussion.
32942923 2020. A Review of the Preclinical and Clinical Efficacy of Remdesivir, Hydroxychloroquine, and Lopinavir-Ritonavir Treatments against COVID-19.
32944838 2020. Pulmonary administration of remdesivir in the treatment of COVID-19.
32963442 2020. Past, Present, and Future of Remdesivir: An Overview of the Antiviral in Recent Times.
32967965 2020. Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action.
32968487 2020. The use of remdesivir outside of clinical trials during the COVID-19 pandemic.
32986807 2020. Remdesivir failure with SARS-CoV-2 RNA-dependent RNA-polymerase mutation in a B-cell immunodeficient patient with protracted Covid-19.
32988821 2020. Captisol and GS-704277, but not GS-441524, are credible mediators of remdesivir's nephrotoxicity.
33006138 2020. Acetylcysteine for the Treatment of Suspected Remdesivir-Associated Acute Liver Failure in COVID-19: A Case Series.
33009111 2020. A Potential Antiviral Treatment for COVID-19: Remdesivir.
33009120 2020. A Potential Antiviral Treatment for COVID-19: Remdesivir.
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33015819 2020. Remdesivir-COVID-19: drug interactions in dentistry.
33015938 2020. A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2.
33017170 2020. Remdesivir for Adults With COVID-19 : A Living Systematic Review for an American College of Physicians Practice Points.
33017175 2020. Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 1).
33028676 2020. Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
33031500 2020. Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19.
33031623 2020. Tackling COVID-19 Using Remdesivir and Favipiravir as Therapeutic Options.
33041326 2020. Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice.
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33055231 2020. Remdesivir against COVID-19 and Other Viral Diseases.
33060041 2020. Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review.
33065096 2020. Computational and theoretical exploration for clinical suitability of Remdesivir drug to SARS-CoV-2.
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33077424 2020. Covid-19: Remdesivir has little or no impact on survival, WHO trial shows.
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33088576 2020. Critical reappraisal of remdesivir investigational trials in COVID-19.
33091434 2020. Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes.
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33100032 2020. Exploring RdRp-remdesivir interactions to screen RdRp inhibitors for the management of novel coronavirus 2019-nCoV.
33103195 2020. Sustained response after remdesivir and convalescent plasma therapy in a B-cell depleted patient with protracted COVID-19.
33105618 2020. Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing.
33109039 2020. The Binding of Remdesivir to SARS-CoV-2 RNA-Dependent RNA polymerase May Pave The Way Towards the Design of Potential Drugs for COVID-19 Treatment.
33117850 2020. Remdesivir Use Compared With Supportive Care in Hospitalized Patients With Severe COVID-19: A Single-Center Experience.
33118617 2020. Effect of remdesivir on mortality in patients with COVID-19: A meta-analysis of randomized control trials.
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33124007 2020. Remdesivir: Critical Clinical Appraisal for COVID 19 Treatment.
33124786 2020. Nucleotide analogues as inhibitors of SARS-CoV Polymerase.
33128490 2020. Efficacy and safety of remdesivir in hospitalized Covid-19 patients: Systematic review and meta-analysis including network meta-analysis.
33130588 2020. Use of remdesivir in the presence of elevated LFTs for the treatment of severe COVID-19 infection.
33136164 2020. Remdesivir for the Treatment of Severe COVID-19: A Community Hospital's Experience.
33139290 2020. New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19.
33139967 2020. Remdesivir in COVID-19 management: availability and relevance to low- and middle-income countries.
33163977 2020. Marked Sinus Bradycardia Associated With Remdesivir in COVID-19: A Case and Literature Review.
33179852 2020. Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.
33185784 2020. Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment.
33190493 2020. Revealing the Inhibition Mechanism of RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 by Remdesivir and Nucleotide Analogues: A Molecular Dynamics Simulation Study.
33200304 2020. Compassionate use of remdesivir in children with COVID-19.
33204761 2020. Remdesivir Use in Patients Requiring Mechanical Ventilation due to COVID-19.
33206336 2020. Remdesivir versus ritonavir/lopinavir in COVID-19 patients.
33208020 2020. CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target.
33210457 2020. Remdesivir: A beacon of hope from Ebola virus disease to COVID-19.
33211457 2012. Remdesivir
33214186 2020. Covid-19: What now for remdesivir?
33229331 2020. Remdesivir for severe covid-19: a clinical practice guideline.
33229428 2020. A Valid Warning or Clinical Lore: An Evaluation of Safety Outcomes of Remdesivir in Patients with Impaired Renal Function from a Multicenter Matched Cohort.
33229429 2020. Off-target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent.
33231938 2020. Is remdesivir important in clinical practice as a treatment against COVID19? A study based on metaanalysis data.
33234758 2020. Convalescent plasma therapy and remdesivir duo successfully salvaged an early liver transplant recipient with severe COVID-19 pneumonia.
33240723 2020. Cardiac Adverse Events With Remdesivir in COVID-19 Infection.
33245577 2020. Clinical studies assessing the efficacy, effectiveness, and safety of remdesivir in management of COVID-19: a scoping review.
33248473 2020. The place for remdesivir in COVID-19 treatment.
33251541 2020. Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent haemodialysis.
33252992 2020. Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implications.
33260103 2020. Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2.
33263094 2020. Remdesivir in patients with estimated glomerular filtration rate < 30mL/min/1.73m(2) or on renal replacement therapy.
33264025 2020. Remdesivir Strongly Binds to Both RNA-Dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations.
33267759 2020. Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance.
33280995 2020. Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC-MS/MS.
33283177 2020. Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase.
33289021 2020. A survey of US hospitals' criteria for the allocation of remdesivir to treat COVID-19.
33296558 2020. A Mechanism-based Pharmacokinetic Model of Remdesivir Leveraging Interspecies Scaling to Simulate COVID-19 Treatment in Humans.
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C7317081 2020. New potential interaction with emergency COVID-19 medicine remdesivir.
C7348117 2020. Remdesivir: Various toxicities: 4 case reports.
C7677433 2020. Lopinavir/ritonavir/remdesivir: Drug induced liver injury and off label use: 5 case reports.
C7726273 2020. Remdesivir: Intrahepatic cholestasis of pregnancy following compassionate use of remdesivir: case report.
32441826 2020. Antiviral treatment using the adenosine nucleoside analogue GS-441524 in cats with clinically diagnosed neurological feline infectious peritonitis.
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