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Two of them, EGL1 and EPAS1, have been previously found, and both seem to be related to how much hemoglobin is in the blood.Hemoglobin is what carries oxygen in the blood. When you acclimate to higher altitudes, your body adjusts to the low oxygen concentrations by making more hemoglobin to suck up more of that hard to get oxygen.The two genes, EGL1 and EPAS1, found in Tibetan populations seem to be doing the opposite: they seem to be decreasing the hemoglobin concentrations.This makes no sense, until you realize that having blood thick with hemoglobin makes your heart pump harder and your vessels strain more. Having a heart that works harder all the time, coupled with vessels that are strained, doesn't add up to a healthy individual.
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