Unproven ideas
coviki.org collects the really good Ideas and the scientific Record on Covid-19 Virus.
- Hypothesis SARS CoV2 as reactivated sleeper virus
- Caplacizumab TTP therapeutic antibody at vWF
- Aprotinin non-specific proteinase inhibitor
| 32883951 2020. COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm |
32813286 2020. Behavioural manipulation - key to the successful global spread of the new Coronavirus SARS-Cov-2?
A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea. This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents. Paper is (not yet in PubMed) :
credentials to Marinus Brandl who told us about it today. based on e.g.
| 32408336 2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets |
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COVID19 is now a CURABLE disease !!!
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My personal bet on the concept of basic resilience Heparin Colchicine Magnesium Noscapine Glutathion
My personal bet on therapeutic escalation Dexamethasone Baricitinib
| 20436917 2010. Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication |
| 32442263 2020. It is time for computable evidence synthesis: The COVID-19 Knowledge Accelerator Initiative. |
32451323 2020. COVID-19: has EBM been replaced by hype-based medicine?
32439723 2020. Covid-19: Each discarded face mask is a potential biohazard.
| 32337769 2020. (tt bradykinin) Noscapine, a possible drug candidate for attenuation of cytokine release associated with SARS-CoV-2 |
32311318 ä. SARS-CoV-2 and viral sepsis: observations and hypotheses
32325026 2020. Endothelial cell infection and endotheliitis in COVID-19
| 32205092 ä. TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib |
32302401 2020. Targeting potential drivers of COVID-19: Neutrophil extracellular traps
32352407 2020. Preventing cytokine storm syndrome in COVID-19 using alpha-1 adrenergic receptor antagonists
32340759 ä. Inappropriate Antibiotic Consumption as a Possible Cause of Inflammatory Storm and Septic Shock in Patients Diagnosed with Coronavirus Disease 2019 (COVID-19)
32359101 2020. A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications personally top relevenat bk activates trpm7 mg channel/kinase causing various effects
32338605 2020. Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome
32065055 2020. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
C7118608 ä. A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19: The Artificial-Liver Blood-Purification System
