Magnesium Amiloride

Aktuelle Version vom 1. Dezember 2021, 22:18 Uhr

First to retrieve from the literature, potassium-saving diuretic amiloride inhibits magnesium egression from intraleccular to extracellular space thus ... inhibiting trpm7 activity (putative). Given the main readout of actual biblio.

Next useful candidate is triamterene (not shown) and to look for, aldosterone antagonists.

Obviously, HCT hydrochlorothiazide, which is commonly co-administrated with ACEI/AT11RA; Amlodipine should be condsidered from omission of medication in the vulnerable populations, biblio not done yet on this aspect: claim 2021 nov 29th.

A little readout on moremed: covid AND amiloride

Search term is moremed: mg AND amiloride

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15550561 2005. Basolateral Mg2+/Na+ exchange regulates apical nonselective cation channel in sheep rumen epithelium via cytosolic Mg2+.
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11123250 2001. Effect of extracellular Mg(2+) on ROS and Ca(2+) accumulation during reoxygenation of rat cardiomyocytes.
11045947 2000. Inhibition of NHE protects reoxygenated cardiomyocytes independently of anoxic Ca(2+) overload and acidosis.
19482897 2009. ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry.
28274923 2017. Effect of diuretics on renal tubular transport of calcium and magnesium.
10518705 1999. Characterization of Mg(2+) efflux from rat erythrocytes non-loaded with Mg(2+).
7880850 1995. Reversibility of Na+/Mg2+ antiport in rat erythrocytes.
7013841 1981. Stimulation of Na:H exchange by insulin.
1576058 1992. Intracellular free magnesium in lymphocytes from patients with congestive cardiac failure treated with loop diuretics with and without amiloride.
6640198 1983. Dose-dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats.
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6825079 1983. Effect of cancer cachexia and amiloride treatment on the intracellular sodium content in tissue cells.
6847785 1983. Effects of amiloride on tumor growth and intracellular element content of tumor cells in vivo.
9790249 1998. Effects of insulin on intracellular magnesium of platelets.
8737071 1996. Characterization of a sodium-dependent magnesium efflux from magnesium-loaded rat pancreatic acinar cells.
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2365055 1990. Induction of Mn2+/H+ antiport in chicken erythrocytes by intracellular Mg2+ and Mn2+.
1689673 1990. Species-specific Mn2+/Mg2+ antiport from Mg2(+)-loaded erythrocytes.
2541009 1989. Na+-independent Mg2+ efflux from Mg2+-loaded human erythrocytes.
15769661 2005. Evaluation of magnesium fluxes in rat erythrocytes using a stable isotope of magnesium.
15769659 2005. Evidence for simultaneous 1Na+:1Mg2+ and ping pong 2Na+:1Mg2+ exchangers in rat thymocyte.
10922295 2000. Epithelial magnesium transport and regulation by the kidney.
12958315 2003. Ca2+-dependent modulation of intracellular Mg2+ concentration with amiloride and KB-R7943 in pig carotid artery.
11278387 2001. Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms.
10660526 2000. Differential localization and operation of distinct Mg(2+) transporters in apical and basolateral sides of rat liver plasma membrane.
8798689 1996. Angiotensin II and vasopressin modulate intracellular free magnesium in vascular smooth muscle cells through Na+-dependent protein kinase C pathways.
2989338 1985. Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules.
22411011 2012. The conductance of red blood cells from sickle cell patients: ion selectivity and inhibitors.
8735697 1996. Mechanisms of manganese transport in rabbit erythroid cells.
8568645 1995. Mechanisms of intracellular Mg2+ regulation affected by amiloride and ouabain in the guinea-pig taenia caeci.
1822527 1991. Sodium-dependent magnesium uptake by ferret red cells.
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3443939 1987. Some properties of a system for sodium-dependent outward movement of magnesium from metabolizing human red blood cells.
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32927908 2020. Inhibition of Mg(2+) Extrusion Attenuates Glutamate Excitotoxicity in Cultured Rat Hippocampal Neurons.
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21060812 2010. Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.
3414406 1988. Amiloride prevents thiazide-induced intracellular potassium and magnesium losses.
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7872368 1995. Treatment of idiopathic renal magnesium wasting with amiloride.
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9729507 1998. Mg2+/Ca2+ sensing inhibits hormone-stimulated Mg2+ uptake in mouse distal convoluted tubule cells.
9755053 1998. Characterization of two Mg2+ transporters in sealed plasma membrane vesicles from rat liver.
9815041 1998. Acute effect of EtOH on Mg2+ homeostasis in liver cells: evidence for the activation of an Na+/Mg2+ exchanger.
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2146883 1990. Basal and stretch-augmented natriuretic peptide secretion by quiescent rat atria.
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3929622 1985. Effect of calcium on transport characteristics of cultured proximal renal cells.
3789649 1986. Cardiac arrhythmias in hypertensive outpatients on various diuretics. Correlation between incidence and serum potassium and magnesium levels.
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7509147 1994. Characterization of magnesium efflux from Ehrlich ascites tumor cells.
3521522 1986. Intracellular cations and diuretic therapy following acute myocardial infarction.
5351243 1969. Amiloride hydrochloride, a hypercalciuric diuretic.
12056828 2002. Magnesium influx enhanced by nitric oxide in hypertensive rat proximal tubule cells.
11563847 2001. Polyvalent cation-sensing mechanism increased Na(+)-independent Mg(2+) transport in renal epithelial cells.
2454102 1988. Amiloride increases the sensitivity of particulate guanylate cyclase to atrial natriuretic factor.
3689385 1987. Characterization of Na+/Mg2+ antiport by simultaneous 28Mg2+ influx.
2992474 1985. Mg2+ efflux is accomplished by an amiloride-sensitive Na+/Mg2+ antiport.
8391320 1993. Na(+)- and anion-dependent Mg2+ influx in isolated hepatocytes.
2139797 1990. Characterization of Na(+)-dependent Mg2+ efflux from Mg2(+)-loaded rat erythrocytes.
6320883 1984. Reconstituted amiloride-inhibited sodium transporter from rabbit kidney medulla is responsible for Na+-H+ exchange.
10958159 2000. Aminoglycosides inhibit hormone-stimulated Mg2+ uptake in mouse distal convoluted tubule cells.
3342421 1988. Influence of chronic diuretic therapy on serum, lymphocyte and erythrocyte potassium, magnesium and calcium concentrations.
3880686 1985. Blood pressure lowering and potassium conservation by triamterene-hydrochlorothiazide and amiloride-hydrochlorothiazide in hypertension.
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6389077 1984. Effects of diuretics on the renal handling of magnesium.
1486902 1992. Modulation of electrolyte excretion by potassium retaining diuretics.
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9828151 1998. Effects of insulin and insulin-like growth factor-1 on intracellular magnesium of platelets.
7505654 1993. Poorly selective cation channels in apical membranes of epithelia.
10489391 1999. Activation of the Na(+)-H+ exchanger modulates angiotensin II-stimulated Na(+)-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension.
2935488 1985. Phorbol ester-induced adhesion (binding) among human mononuclear leukocytes requires extracellular Mg++ and is sensitive to protein kinase C, lipoxygenase, and ATPase inhibitors.
1714010 1991. Antiarrhythmic activity of amiloride: mechanisms.
2441176 1987. Effect of chronic diuretics on epinephrine-induced ventricular arrhythmias: a comparison of hydrochlorothiazide and amiloride in the rat.
9491781 1998. Attenuation of apoptotic DNA fragmentation by amiloride.
6806306 1982. Inhibition of the serum-dependent, amiloride-sensitive sodium transport pathway in human fibroblasts by extracellular divalent cations.
17041782 2006. Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells.
7807526 1994. Sodium transport through the amiloride-sensitive Na-Mg pathway of hamster red cells.
3598912 1987. Magnesium deficiency produces endothelium-dependent vasorelaxation in canine coronary arteries.
5133613 1971. Effects of the chronic administration of amiloride hydrochloride (N-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate) on electrolyte balance in the dog.
8861131 1995. Mechanisms responsible for the increased magnesium efflux associated with raised [Na+]o in the isolated perfused rat heart.
1591140 1992. Triamterene may preserve lymphocyte magnesium and potassium in patients with congestive heart failure.
3079202 1988. The control of red cell magnesium.
1814319 1991. Mg2+ influx into Mg(2+)-depleted reticulocytes.
2130826 1990. Na(+)-dependent Mg2+ efflux from Mg(2+)-loaded rat thymocytes and HL 60 cells.
2123389 1990. Sodium-calcium exchange mechanism in vascular smooth muscle tissue as revealed by manipulating external magnesium.
2661928 1989. Cellular concentration of magnesium and other ions in relation to protein synthesis, cell proliferation and cancer.
3669732 1987. Amiloride-sensitive net Mg2+ efflux from isolated perfused rat hearts.
3543514 1986. Magnesium and potassium-sparing diuretics.
6536837 1984. Magnesium- and potassium-sparing effects of amiloride. Review and recent findings.
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1507935 1992. Heart failure and electrolyte disturbances.
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2277603 1990. Intracellular alkalosis induced by increas-ing extracellular potassium. Ionic dependence and effects of amiloride and DIDS.
17415622 2007. Functional characterization of two distinct Mg(2+) extrusion mechanisms in cardiac sarcolemmal vesicles.
8569727 1995. Second messenger role of magnesium in pancreatic acinar cells of the rat.
1690355 1990. Dual ion-channel regulation by cyclic GMP and cyclic GMP-dependent protein kinase.
181683 1976. Non-specific inhibition of membrane-ATPase by amiloride: a comparative in vivo and in vitro study with ouabain.
9481715 1998. Effect of an increase in the plasma potassium concentration on renal magnesium handling in healthy volunteers.
4000346 1985. Effect of amiloride on experimental gentamicin nephrotoxicity.
1963475 1990. Amiloride blocks glutamate-operated cationic channels and protects neurons in culture from glutamate-induced death.
5145537 1971. Role des antikaliuretiques et des catecholamines dans la prevention de necroses cardiaques d'origine metabolique.
8781193 1996. Magnesium transport in magnesium-loaded ferret red blood cells.
2755900 1989. Direct effects of furosemide and amiloride on the perfused and ischaemic rat heart.
3432204 1987. Prolonged diuretic administration and myocardial tolerance to ischaemia.
3575250 1987. Tissue electrolyte changes induced by high doses of diuretics in rats.
7533306 1994. Intracellular Ca(2+)-Mg2+ interactions.
8059093 1994. Magnesium regulates ion transport across canine tracheal epithelium.
5135405 1971. Effect d'antikaliuretiques dans le developpement des lesions cardiaques chez le rat deficient en potassium ou en magnesium.
6879384 1983. Prophylaxis and treatment of magnesium depletion.
7025258 1981. Antihypertensive and metabolic effects of a combination of hydrochlorothiazide and amiloride.
2609140 1989. Wirkung von Trichlormethiazid und Amilorid auf die zellulare Na+-, K+- und Mg2+-Konzentration.