Hydroxychloroquine

Version vom 23. Juni 2020, 12:59 Uhr

• check retina status; monitor rhythm known toxicity
• 91% benefit
• approval russia
• scale up production
• on safety, trial
• Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 substance is useless.

32232419 ä. Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know
32227189 ä. A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19
32147496 2020. Of chloroquine and COVID-19
32074550 2020. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies
32321905 2020. Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database
32281583 2020. Update on use of chloroquine/hydroxychloroquine to treat coronavirus disease 2019 (COVID-19)
32265182 2020. Should chloroquine and hydroxychloroquine be used to treat COVID-19? A rapid review
32194981 2020. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
32371558 2020. Hydroxychloroquine use in the COVID-19 patient
32150618 ä. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
32211771 ä. Could Chloroquine /Hydroxychloroquine Be Harmful in Coronavirus Disease 2019 (COVID-19) Treatment?
32211764 ä. Is Hydroxychloroquine a Possible Postexposure Prophylaxis Drug to Limit the Transmission to Healthcare Workers Exposed to Coronavirus Disease 2019?
32255489 ä. Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients
32306288 ä. Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties
32269021 2020. Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection
32345336 2020. Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2
32351851 ä. A Coronavirus Disease 2019 (COVID-19) Patient with Multifocal Pneumonia Treated with Hydroxychloroquine
32340837 ä. Hydroxychloroquine in Covid-19: Does the end justify the means?
32247211 2020. Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search and a narrative review with a special reference to India and other developing countries
32321878 2020. Is GSK3beta a molecular target of chloroquine treatment against COVID-19?
32371138 ä. Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19
32266694 ä. Chloroquine for COVID-19 Infection
32373183 2020. Chloroquine and hydroxychloroquine in the context of COVID-19
32338155 2020. Rheumotologitsts view on the use of hydroxychloroquine to treat COVID-19
32347923 ä. Chloroquine and hydroxychloroquine for COVID-19: implications for cardiac safety
32212513 2020. The Trial of Chloroquine in the Treatment of Corona Virus Disease 2019 COVID-19 and Its Research Progress in Forensic Toxicology
32363145 ä. An algorithm for managing QT prolongation in coronavirus disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin: Possible benefits of intravenous lidocaine
32363144 ä. Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin
32341910 2020. SARS-CoV-2 infection in a patient on chronic hydroxychloroquine therapy: Implications for prophylaxis
32278018 ä. Cardiovascular risks of hydroxychloroquine in treatment and prophylaxis of COVID-19 patients: A scientific statement from the Indian Heart Rhythm Society
32335560 2020. Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials
32205204 ä. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
32171740 ä. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
32070753 2020. Chloroquine for the 2019 novel coronavirus SARS-CoV-2
C7152897 ä. Chloroquine as prophylactic agent against COVID-19?
32194152 ä. Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine
32145363 2020. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19
32363157 2020. Chloroquine: Can it be a Novel Drug for COVID-19
32283236 ä. Does hydroxychloroquine combat COVID-19? A timeline of evidence
32330546 ä. Inpatient Use of Ambulatory Telemetry Monitors for COVID-19 Patients Treated with Hydroxychloroquine and/or Azithromycin
32281268 2020. G6PD and chloroquine: Selecting the treatment against SARS?CoV?2?
32356863 ä. Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)
32356858 ä. Assessment of QT Intervals in a Case Series of Patients With Coronavirus Disease 2019 (COVID-19) Infection Treated With Hydroxychloroquine Alone or in Combination With Azithromycin in an Intensive Care Unit
32330277 2020. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial
32339248 2020. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial
32363144 ä. Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin
32251731 ä. Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
32283237 ä. Hydroxychloroquine and ivermectin: a synergistic combination for COVID-19 chemoprophylaxis and/or treatment?
32283123 ä. Considerations for Drug Interactions on QTc in Exploratory COVID-19 (Coronavirus Disease 2019) Treatment
32196083 ä. COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
32236561 ä. Combating COVID-19 with Chloroquine
32281481 2020. Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review
32365215 2020. Behandling med 4-aminokinoliner vid covid-19 kan ge allvarliga biverkningar
32278373 2020. Regulators split on antimalarials for COVID-19
32359771 ä. Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19)
32304640 ä. Hydroxychloroquine in the management of critically ill patients with COVID-19: the need for an evidence base
32368738 2020. Excitement around hydroxychloroquine for treating COVID-19 causes challenges for rheumatology
32311322 ä. Chloroquine or hydroxychloroquine for prophylaxis of COVID-19
32311324 ä. Hydroxychloroquine prophylaxis for COVID-19 contacts in India
32322402 2020. Review on the global epidemiological situation and the efficacy of chloroquine and hydroxychloroquine for the treatment of COVID-19
32316270 2020. COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help
32231349 2020. Chloroquine in COVID-19: the evidence
32217166 2020. Chloroquine and COVID-19, where do we stand??
32240719 ä. No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection
32350818 ä. Chloroquine-induced QTc prolongation in COVID-19 patients
32344177 2020. In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
32305500 ä. Chloroquine paradox may cause more damage than help fight COVID-19
32322397 2020. Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance
32327397 ä. Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine
32363212 ä. Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19)
32292817 2020. Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19
32267301 ä. Driving forces for COVID-19 clinical trials using chloroquine: the need to choose the right research questions and outcomes
32347963 2020. An independent appraisal and re-analysis of hydroxychloroquine treatment trial for COVID-19
32247518 2020. COVID-19 and Chloroquine/Hydroxychloroquine: is there Ophthalmological Concern?

32289548 2020. Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study
32247925 ä. Repurposing antimalarials and other drugs for COVID-19
32380315 ä. Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis
32348551 2020. Response to: Optimizing Hydroxychloroquine Dosing for Patients With COVID-19: An Integrative Modeling Approach for Effective Drug Repurposing: Quantitative Clinical Pharmacology Input to SARS-CoV-2 Therapeutics Should Be Based on Robust Data
32297988 2020. Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis
32173110 2020. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19
32347894 2020. The Risks of Prescribing Hydroxychloroquine for Treatment of COVID-19-First, Do No Harm
32236562 2020. Treating COVID-19 with Chloroquine
32333649 2020. The friendly use of chloroquine in the COVID-19 disease: a warning for the G6PD-deficient males and for the unaware carriers of pathogenic alterations of the G6PD gene
32379955 ä. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19
32285489 2020. Chloroquine and Hydroxychloroquine in the Era of SARS - CoV2: Caution on Their Cardiac Toxicity
17806092 2008. Ferrocene Conjugates of Chloroquine and other Antimalarials: the Development of Ferroquine, a New Antimalarial
32164085 2020. Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia

C7162107 2020. Chloroquin gegen Corona?
C7197234 2020. Safety concerns with higher dosage chloroquine in COVID-19 patients
C7197245 2020. Antimalarial use in COVID-19 patients requires close monitoring
32167254 2020. Epidemie de coronavirus et polemique sur la chloroquine
32270942 2020. Covid-19, dans les brouillards francais de l'hydroxychloroquine
32301315 2020. Covid-19, dans les brouillards de l'hydroxychloroquine (2)
32381323 ä. Acute hemolysis by hydroxycloroquine was observed in G6PD-deficient patient with severe COVD-19 related lung injury

32294495 ä. Chloroquine as a prophylactic agent against COVID-19?
C7184982 ä. Ventricular arrhythmia risk due to chloroquine / hydroxychloroquine treatment for COVID-19: Should it be given

32402766 2020. Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection
32451138 ä. ...surveillance ophtalmologique ...hydroxychloroquine e...
32408070 2020. Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win todays battle against COVID-19?
32386744 ä. Uso de antipaludicos (antimalarials)...
24773578 2014. Chloroquine interferes with dengue?2 virus replication in U937 cells
32409150 ä. An evaluation of co-use of chloroquine or hydroxychloroquine plus azithromycin on cardiac outcomes: A pharmacoepidemiological study to inform use during the COVID19 pandemic
32286537 ä. Hydroxychloroquine: small effects in mild disease
32418730 ä. ?Off-label? use of hydroxychloroquine, azithromycin, lopinavir-ritonavir and chloroquine in COVID-19: A survey of cardiac adverse drug reactions by the French Network of Pharmacovigilance Centers
32331804 ä. Hydroxychloroquine and ?off-label? utilization in the treatment of oral conditions

32387409 ä. Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France
32387694 ä. Therapeutic use of chloroquine and hydroxychloroquine in COVID-19 and other viral infections: A narrative review
32442941 2020. Hidroxicloroquina. Mensajes desde la cardiologia en tiempos de pandemia por coronavirus.
32458599 2020. [Pharmacological characteristics of chloroquine and suggestions for its use in treatment of coronavirus disease 2019 (COVID-19)].
32075365 2020. [Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia].
32498009 2020. Mass intake of hydroxychloroquine or chloroquine in the present context of the Covid-19 outbreak: Possible consequences in endemic malaria settings.
32500556 2020. Doubtful precipitation of hemolysis by hydroxychloroquine in glucose-6-phosphate dehydrogenase deficient patient with COVID-19 infection.
32474476 2020. Risk of using hydroxychloroquine as a treatment of COVID-19.
32432527 2020. Hydroxychloroquine against COVID-19: A critical appraisal of the existing evidence.
32380930 2020. Chloroquine and the potential adverse outcome in undiagnosed G6PD-deficient cases infected with COVID-19.
32435791 2020. Connecting hydroxychloroquine in vitro antiviral activity to in vivo concentration for prediction of antiviral effect: a critical step in treating COVID-19 patients.
32237918 2020. Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution.
32303497 2020. Chloroquine and COVID-19 - a potential game changer?

32321722 2020. To consider or not antimalarials as a prophylactic intervention in the SARS-CoV-2 (COVID-19) pandemic.
32317316 2020. Hydroxychloroquine reduces the risk of covid-19 in patients with rheumatic diseases: myth or reality?
32317315 2020. Is there a future for hydroxychloroquine/chloroquine in prevention of SARS-CoV-2 infection (COVID-19)?

32327429 2020. Can hydroxychloroquine protect patients with rheumatic diseases from COVID-19? Response to: 'Does hydroxychloroquine prevent the transmission of COVID-19?' by Heldwein and Calado and 'SLE, hydroxychloroquine and no SLE patients with COVID-19: a comment' by Joob and Wiwanitkit.
32295788 2020. Does hydroxychloroquine prevent the transmission of COVID-19?
32295786 2020. Festina lente: hydroxychloroquine, COVID-19 and the role of the rheumatologist.
32345618 2020. Response to 'Is there a future for hydroxychloroquine/chloroquine in prevention of SARS-CoV-2 infection (COVID-19)?' by Moiseev et al.

32474576 2020. Dose Optimization of Hydroxychloroquine for COVID-19: Do Blood Concentrations Matter?
32501756 2020. Association of Hydroxychloroquine with QTc Interval in Patients with COVID-19.
32267732 2020. Considerations for Drug Interactions on QTc in Exploratory COVID-19 Treatment.
32415690 2020. Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam.
32436730 2020. Use of Chloroquine and Hydroxychloroquine in COVID-19 and Cardiovascular Implications: Understanding Safety Discrepancies to Improve Interpretation and Design of Clinical Trials.
32347743 2020. Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection.
32430461 2020. Lack of efficacy of hydroxychloroquine in covid-19.
32503805 2020. Covid-19: Hydroxychloroquine was ineffective as postexposure prophylaxis, study finds.
32487664 2020. Covid-19: 146 researchers raise concerns over chloroquine study that halted WHO trial.
32269046 2020. Chloroquine and hydroxychloroquine in covid-19.
32469265 2020. Docking study of Chloroquine and Hydroxychloroquine interaction with SARS-CoV-2 spike glycoprotein-An in silico insight into the comparative efficacy of repurposing antiviral drugs.
32438459 2020. Efficacy, safety and cost-effectiveness of hydroxychloroquine in children with COVID-19: A call for evidence.
32473020 2020. Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial.
32457980 2020. Failure of hydroxychloroquine pre-exposure prophylaxis in COVID-19 infection? A case report.

32474918 2020. An open label cluster randomized controlled trial of chloroquine, hydroxychloroquine or only supportive care in patients admitted with moderate to severe COVID-19 (ARCHAIC) - Protocol publication.
32324363 2020. [A szerzett hosszu-QT-szindroma veszelye a koronavirus-jarvany idejen. Fokuszban a hidroxiklorokin]
32458488 2020. Potential negative effects of the free use of chloroquine to manage COVID-19 in Colombia.
32434282 2020. Hydroxychloroquine and Azithromycin to Treat Patients With COVID-19: Both Friends and Foes?
32448039 2020. In-silico strategies for probing chloroquine based inhibitors against SARS-CoV-2.
32295814 2020. Hydroxychloroquine and covid-19.
32496926 2020. Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19.
32488217 2020. The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin.

32496442 2020. Why G6PD Deficiency Should Be Screened Before COVID-19 Treatment With Hydroxychloroquine?
32490532 2020. HyPE study: hydroxychloroquine prophylaxis-related adverse events' analysis among healthcare workers during COVID-19 pandemic: a rising public health concern.
32492298 2020. Hydroxychloroquine for the Prevention of Covid-19 - Searching for Evidence.
32492293 2020. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.

32400382 2020. [Brug af hydroxychloroquin til COVID-19].
32400380 2020. [Lack of clinical evidence for the use of hydroxychloroquine to treat SARS-CoV-2 infection].
32391667 2020. [A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].
32402475 2020. Adverse drug reactions of hydroxychloroquine: Analysis of French pre-pandemic SARS-CoV2 pharmacovigilance data.
32348059 2020. COVID-19, dans les brouillards de l'hydroxychloroquine (4).
32320161 2020. Covid-19, dans les brouillards de l'hydroxychloroquine (3).

32393664 2020. Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.
32451353 2020. Evidence of Protective Effect of Hydroxychloroquine on COVID-19.
32474406 2020. The rediscovery of hydroxychloroquine in allergic diseases in the COVID-19 era.
32463348 2020. Experience With Hydroxychloroquine and Azithromycin in the Coronavirus Disease 2019 Pandemic: Implications for QT Interval Monitoring.
32463308 2020. Chloroquine or Hydroxychloroquine for COVID-19: Is Cardiotoxicity a Concern?
32496241 2020. Hydroxychloroquine as prophylaxis or treatment for COVID-19: What does the evidence say?