PHA SCR nsp3 signal transduction modulator

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PHA pharmacophore by screened target
living current stringent pubmed readout on nsp3

"suggest de-mono-ADP-ribosylation (de-MARylation) of STAT1 by the SARS-CoV-2 nsp3 as a putative cause of the cytokine storm observed in the most severe cases of COVID-19" 32549200

both nsp2 and nsp3 are coded in orf1ab see 32083328

32083328 ä. COVID?2019: The role of the nsp2 and nsp3 in its pathogenesis

29128390 2018. Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

32578982 2020. Molecular Basis for ADP-ribose Binding to the Mac1 Domain of SARS-CoV-2 Nsp3.

32549200 2020. A Putative Role of de-Mono-ADP-Ribosylation of STAT1 by the SARS-CoV-2 Nsp3 Protein in the Cytokine Storm Syndrome of COVID-19.
32563187 2020. Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation.

32828990 2020. The use of knowledge management tools in viroinformatics. Example study of a highly conserved sequence motif in Nsp3 of SARS-CoV-2 as a therapeutic target.
32835090 2020. In Silico Identification of Potential Inhibitors of ADP-Ribose Phosphatase of SARS-CoV-2 nsP3 by Combining E-Pharmacophore- and Receptor-Based Virtual Screening of Database.
32981460 2020. Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3.
33185784 2020. Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment.

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