Candidate Compounds Covid19

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A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea.
+
*'''[[scouting ideas]]'''
This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world
+
vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents.
+
Paper is (not yet in PubMed) :
+
 
+
*'''[https://www.sciencedirect.com/science/article/pii/S1097276520305499?via%3Dihub Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication at Mol Cell 2020/08/11]'''
+
credentials to [https://web.de/magazine/news/coronavirus/coronavirus-blockade-zellulaerer-kommunikation-forscher-stoppen-vermehrung-sars-cov-2-35045170 Marinus Brandl] who told us about it today.
+
based on e.g.
+
 
+
{{ttp|p=32408336|t=2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets |pdf=|usr=}}
+
 
+
=======================================================================================
+
 
+
COVID19 is now a CURABLE disease !!!
+
 
+
=======================================================================================
+
 
+
 
+
*[[scouting ideas]]
+
  
 
*'''[[PHA Biologicals]]'''
 
*'''[[PHA Biologicals]]'''
 
*[[Patients on biologicals]]
 
*[[HMGB1, RAGE]]
 
*[[pre-Interleukin 6]]
 
*[[post-Interleukin 6]]
 
*[[pre-TNFalpha]]
 
*[[post-TNFalpha]]
 
*[[pre-Interleukin 17]]
 
*[[post-Interleukin 17]]
 
*[[pre-Interleukin 1]]
 
*[[post-Interleukin 1]]
 
*[[Inflammasome]] ''colchicine''
 
*[[NK-kappaB]]
 
*[[STAT 3]]
 
*[[JAK Janus Kinase]]
 
*[[Corticosteroids]]
 
*[[Cytokine absorbers]]
 
*[[other anti-inflammatory]]
 
*'''[[MDSC cells]]''' top item !
 
*[[Target Neurophils]]
 
*[[Target Mast cells]] and kinins
 
*[[Anticoagulant in covid19]]
 
*[[Target Complement system]]
 
*[[Target Extracellular traps]]
 
*[[Caplacizumab]] vWF(TTP)
 
*[[TGF beta]]
 
*[[Immunosuppressants]]
 
*[[Immunodeviation]] e.g. by adjuvants or other vaccinations
 
*[[Stem cells]]
 
*[[Antioxidants]]
 
*[[HIF-EPO-Iron]]
 
 
  
 
*'''[[PHA conventional pharmacology]]'''
 
*'''[[PHA conventional pharmacology]]'''
*[[Methotrexate]]
 
*[[Antineoplastic agents, traditional]]
 
*[[Tyrosine kinase inhibitors]]
 
*[[Mouthrinses]]
 
*[[Adenosinergic signaling]]
 
*[[Purinergic signaling]]
 
*[[Nicotinergic signaling]]
 
*[[cAMP cGMP PDE NO]]
 
*[[TRPV* channels]]
 
*[[Retinoids]]
 
 
 
  
 
*'''[[PHA retargeted compounds]]'''
 
*'''[[PHA retargeted compounds]]'''
*[[Retargeted Psychopharm]]
 
*[[Hydroxychloroquine]]
 
*[[AV Ivermectin]]
 
*[[Antibiotics]]
 
*[[other single compounds]]
 
  
 
*'''[[PHA antivirals by mechanism]]'''
 
*'''[[PHA antivirals by mechanism]]'''
*[[Interferons]]
 
*[[Target ACE2, Spike protein]]
 
*[[Target TMPRSS2, Spike protein]] ''any other covid targed herein''
 
*[[Aprotinin]] protease inh bradykinin synth. inh.
 
*[[Protease inhibitors]]
 
*[[other antiviral compounds]]
 
*[[AV Remdesivir]]
 
*[[AV Lopinavir]]
 
*[[AV Arabidol]]
 
*[[AV Favipiravir]]
 
*[[AV Molnupiravir]]
 
 
  
 +
*'''[[PHA pharmacophore by screened target]]'''
  
 
*'''[[PHA ImmunoNutrients]]
 
*'''[[PHA ImmunoNutrients]]
*[[Vitamin D]]
 
*[[Anorganic nutrients Magnesium]]
 
*[[Anorganic nutrients Selenium]]
 
*[[Anorganic nutrients Zinc]]
 
*[[Anorganic nutrients Lithium]]
 
*[[Anorganic nutrients Copper]]
 
*[[Anorganic nutrients Bismuth]]
 
*[[Nutrition, general]]
 
*[[Exercise, Vibration]]
 
  
 
*'''[[PHA compl altern natural]]'''
 
*'''[[PHA compl altern natural]]'''
*[[Traditional Chinese Medicine]]
 
*[[Natural compounds]]
 
  
 
*'''[[PHA within indications compounds]]'''
 
*'''[[PHA within indications compounds]]'''
*[[Statins]]
 
*[[Antidiabetic compounds, any]]
 
*[[RSP - On RAS drugs]]
 
*[[RSP - On NSAIDs]]
 
  
 
*'''[[PHA Serum products]]'''
 
*'''[[PHA Serum products]]'''
*[[Reconvalescent blood products, Passive vaccine]]
 
*[[Plasmapheresis]]
 
  
 
*'''[[PHA Vaccination]]'''
 
*'''[[PHA Vaccination]]'''
*[[Active vaccine]]
 
*[[mRNA vaccine]]
 
*[[conventional vaccine]]
 
  
*'''[[PHA related options]]'''
+
PHA related options:
 +
 
 
*[[Radiation therapy]]
 
*[[Radiation therapy]]
 
*[[Phototherapy]]
 
*[[Phototherapy]]
 +
*[[Electric fields]]
 
*[[Treatment other concepts]]
 
*[[Treatment other concepts]]
 +
 +
 +
A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea.
 +
This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world
 +
vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents.
 +
Paper is (not yet in PubMed) :
 +
 +
*'''[https://www.sciencedirect.com/science/article/pii/S1097276520305499?via%3Dihub Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication at Mol Cell 2020/08/11]'''
 +
credentials to [https://web.de/magazine/news/coronavirus/coronavirus-blockade-zellulaerer-kommunikation-forscher-stoppen-vermehrung-sars-cov-2-35045170 Marinus Brandl] who told us about it today.
 +
based on e.g.
 +
 +
{{ttp|p=32408336|t=2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets |pdf=|usr=}}
 +
 +
=======================================================================================
 +
 +
COVID19 is now a CURABLE disease !!!
 +
 +
=======================================================================================

Aktuelle Version vom 21. September 2021, 06:15 Uhr

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PHA related options:


A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea.
This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world
vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents.
Paper is (not yet in PubMed) :

credentials to Marinus Brandl who told us about it today. based on e.g.

32408336 2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets
=======================================================================================
COVID19 is now a CURABLE disease !!!
=======================================================================================

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