Candidate Compounds Covid19
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| + | ...so calm down and enjoy the progress of immediate translational medicine: | ||
| + | A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea. | ||
| + | This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world | ||
| + | vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents. | ||
| + | Paper is (not yet in PubMed) : | ||
| − | + | *'''[https://www.sciencedirect.com/science/article/pii/S1097276520305499?via%3Dihub Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication at Mol Cell 2020/08/11]''' | |
| − | + | credentials to [https://web.de/magazine/news/coronavirus/coronavirus-blockade-zellulaerer-kommunikation-forscher-stoppen-vermehrung-sars-cov-2-35045170 Marinus Brandl] who told us about it today. | |
| − | + | based on e.g. | |
| − | *[[reviews on covid drug development]] | + | {{ttp|p=32408336|t=2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets |pdf=|usr=}} |
| + | |||
| + | ======================================================================================= | ||
| + | |||
| + | COVID19 is now a CURABLE disease !!! | ||
| + | |||
| + | ======================================================================================= | ||
| + | |||
| + | *[[reviews on covid drug development]] | ||
*[[scouting ideas]] | *[[scouting ideas]] | ||
*[[Patients on biologicals]] | *[[Patients on biologicals]] | ||
*[[HMGB1, RAGE]] | *[[HMGB1, RAGE]] | ||
| − | *[[pre-Interleukin 6]] | + | *[[pre-Interleukin 6]] |
*[[post-Interleukin 6]] | *[[post-Interleukin 6]] | ||
*[[pre-TNFalpha]] | *[[pre-TNFalpha]] | ||
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*[[pre-Interleukin 1]] | *[[pre-Interleukin 1]] | ||
*[[post-Interleukin 1]] | *[[post-Interleukin 1]] | ||
| − | *[[Inflammasome]] | + | *[[Inflammasome]] ''colchicine'' |
| + | *[[Methotrexate]] | ||
*[[other anti-inflammatory]] | *[[other anti-inflammatory]] | ||
*[[NK-kappaB]] | *[[NK-kappaB]] | ||
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*[[Target Complement system]] | *[[Target Complement system]] | ||
*[[Target Extracellular traps]] | *[[Target Extracellular traps]] | ||
| + | *[[Caplacizumab]] vWF(TTP) | ||
| + | *[[Target Neurophils]] | ||
| + | *[[Target Mast cells]] and kinins | ||
| + | *[[TGF beta]] | ||
| + | *[[Immunosuppressants]] | ||
*[[Anticoagulant in covid19]] | *[[Anticoagulant in covid19]] | ||
*[[Antioxidants]] | *[[Antioxidants]] | ||
| + | *[[HIF-EPO-Iron]] | ||
*[[Stem cells]] | *[[Stem cells]] | ||
*[[MDSC cells]] | *[[MDSC cells]] | ||
| − | + | *[[Interferons]] | |
| + | *[[cAMP cGMP PDE NO]] | ||
| + | *[[TRPV* channels]] | ||
| + | *[[Retinoids]] | ||
| + | *[[Protease inhibitors]] | ||
| + | *[[Tyrosine kinase inhibitors]] | ||
| + | *[[Antineoplastic agents, traditional]] | ||
| + | *[[Mouthrinses]] | ||
| + | *[[Adenosinergic signaling]] | ||
| + | *[[Purinergic signaling]] | ||
| + | *[[Nicotinergic signaling]] | ||
*[[other single compounds]] | *[[other single compounds]] | ||
| − | *[[Retargeted | + | *[[Retargeted Psychopharm]] |
| − | *[[Hydroxychloroquine]] | + | *[[Hydroxychloroquine]] |
* | * | ||
| − | + | *[[Target ACE2, Spike protein]] | |
| + | *[[Target TMPRSS2, Spike protein]] ''any other covid targed herein'' | ||
| + | *[[Aprotinin]] protease inh bradykinin synth. inh. | ||
*[[other antiviral compounds]] | *[[other antiviral compounds]] | ||
*[[AV Remdesivir]] | *[[AV Remdesivir]] | ||
*[[AV Lopinavir]] | *[[AV Lopinavir]] | ||
*[[AV Ivermectin]] | *[[AV Ivermectin]] | ||
| + | *[[AV Arabidol]] | ||
| + | *[[AV Favipiravir]] | ||
| − | *[[ | + | *[[Antibiotics]] |
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*[[Vitamin D]] | *[[Vitamin D]] | ||
| − | |||
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*[[Anorganic nutrients Magnesium]] | *[[Anorganic nutrients Magnesium]] | ||
*[[Anorganic nutrients Selenium]] | *[[Anorganic nutrients Selenium]] | ||
*[[Anorganic nutrients Zinc]] | *[[Anorganic nutrients Zinc]] | ||
| − | + | *[[Anorganic nutrients Lithium]] | |
| + | *[[Anorganic nutrients Copper]] | ||
| + | *[[Anorganic nutrients Bismuth]] | ||
| + | *[[Nutrition, general]] | ||
| + | *[[Exercise, Vibration]] | ||
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*[[Natural compounds]] | *[[Natural compounds]] | ||
| + | *[[Statins]] | ||
*[[Antidiabetic compounds, any]] | *[[Antidiabetic compounds, any]] | ||
*[[RSP - On RAS drugs]] | *[[RSP - On RAS drugs]] | ||
| + | *[[RSP - On NSAIDs]] | ||
| − | *[[Reconvalescent blood products, Passive vaccine]] | + | *[[Reconvalescent blood products, Passive vaccine]] |
*[[Plasmapheresis]] | *[[Plasmapheresis]] | ||
*[[Immunodeviation]] e.g. by adjuvants or other vaccinations | *[[Immunodeviation]] e.g. by adjuvants or other vaccinations | ||
*[[Radiation therapy]] | *[[Radiation therapy]] | ||
| − | *[[ | + | *[[Phototherapy]] |
| − | + | *[[Active vaccine]] | |
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| − | + | *[[Treatment other concepts]] | |
| + | ---- | ||
Version vom 3. Oktober 2020, 20:18 Uhr
coviki.org collects the really good Ideas and the scientific Record on Covid-19 Virus.
P further streaming-in related content is here
...so calm down and enjoy the progress of immediate translational medicine:
A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea. This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents. Paper is (not yet in PubMed) :
credentials to Marinus Brandl who told us about it today. based on e.g.
| 32408336 2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets |
=======================================================================================
COVID19 is now a CURABLE disease !!!
=======================================================================================
- Patients on biologicals
- HMGB1, RAGE
- pre-Interleukin 6
- post-Interleukin 6
- pre-TNFalpha
- post-TNFalpha
- pre-Interleukin 17
- post-Interleukin 17
- pre-Interleukin 1
- post-Interleukin 1
- Inflammasome colchicine
- Methotrexate
- other anti-inflammatory
- NK-kappaB
- STAT 3
- JAK Janus Kinase
- Corticosteroids
- Cytokine absorbers
- Target Complement system
- Target Extracellular traps
- Caplacizumab vWF(TTP)
- Target Neurophils
- Target Mast cells and kinins
- TGF beta
- Immunosuppressants
- Anticoagulant in covid19
- Antioxidants
- HIF-EPO-Iron
- Stem cells
- MDSC cells
- Interferons
- cAMP cGMP PDE NO
- TRPV* channels
- Retinoids
- Protease inhibitors
- Tyrosine kinase inhibitors
- Antineoplastic agents, traditional
- Mouthrinses
- Adenosinergic signaling
- Purinergic signaling
- Nicotinergic signaling
- other single compounds
- Retargeted Psychopharm
- Hydroxychloroquine
- Target ACE2, Spike protein
- Target TMPRSS2, Spike protein any other covid targed herein
- Aprotinin protease inh bradykinin synth. inh.
- other antiviral compounds
- AV Remdesivir
- AV Lopinavir
- AV Ivermectin
- AV Arabidol
- AV Favipiravir
- Vitamin D
- Anorganic nutrients Magnesium
- Anorganic nutrients Selenium
- Anorganic nutrients Zinc
- Anorganic nutrients Lithium
- Anorganic nutrients Copper
- Anorganic nutrients Bismuth
- Nutrition, general
- Exercise, Vibration
- Immunodeviation e.g. by adjuvants or other vaccinations
- Radiation therapy
- Phototherapy
- Active vaccine
