Spontaneous idea: magnesium and hydroxychloroquine

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The most limiting adverse effect of hcq is cardiac arrythmia caused by qt time prolongation driving torsade de pointes, ventricular fibrillation and asystolic death, ultimately.

I remembered mgso4 is drug of choice in tdp, adjusting the qtc to normal.

Since my best bet since 02/2020 is magnesium, my brain cell said 10 in ago WOW.

The literature on Mg AND hcq/cq shows only binding of drug to magnesium particles i.e. in antacids, but no prophylactic use to circumvent this fnctional toxicity:

http://www.kidney.de/MedlineB.php?Q=(hydroxychloroquine%20OR%20chloroquine)%20AND%20(magnesium%20OR%20trpm7%20OR%20mgso4)&F=AND%201500[PDAT]:2025[PDAT]&Z0=0&ZL=150&Y=&MTB=1&px1=proxy.nationallizenzen.de&px2=&px3=&px4=

My bigger to do list is effects of Mg on QTc time prolongation as it is an established high-efficiency drug.

http://www.kidney.de/MedlineB.php?Q=(qtc%20OR%20qt%20time%20OR%20lqt*%20OR%20qt%20prolongation)%20AND%20(magnesium%20OR%20trpm7%20OR%20mgso4)&F=AND%201500[PDAT]:2025[PDAT]&Z0=0&ZL=150&Y=&MTB=1&px1=proxy.nationallizenzen.de&px2=&px3=&px4=

Tomorrow we will know if Hydroxychloroquine could be made a safe drug by oral magnesium substitution - with phased application of mg and hcq bc inactivation of hcq by mere binding each other.

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