PHA SCR nsp3 signal transduction modulator
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{{up|PHA pharmacophore by screened target}} | {{up|PHA pharmacophore by screened target}} | ||
| − | {{plb|((covid19+OR+covid-19+OR+sars-cov2+OR+sars-cov-2+OR+2019-ncov+OR+2019ncov))+AND+(nsp3+OR+non-structural+protein+3)|nsp3 }} | + | {{plb|((covid19+OR+covid-19+OR+sars-cov2+OR+sars-cov-2+OR+2019-ncov+OR+2019ncov))+AND+(nsp3+OR+non-structural+protein+3+OR+orf1ab)|nsp3 }} |
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"suggest de-mono-ADP-ribosylation (de-MARylation) of STAT1 by the SARS-CoV-2 nsp3 as a putative cause of the cytokine storm observed in the most severe cases of COVID-19" 32549200 | "suggest de-mono-ADP-ribosylation (de-MARylation) of STAT1 by the SARS-CoV-2 nsp3 as a putative cause of the cytokine storm observed in the most severe cases of COVID-19" 32549200 | ||
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| + | both nsp2 and nsp3 are coded in orf1ab see 32083328 | ||
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Aktuelle Version vom 21. April 2021, 20:57 Uhr
| PHA pharmacophore by screened target |
| living current stringent pubmed readout on nsp3 |
"suggest de-mono-ADP-ribosylation (de-MARylation) of STAT1 by the SARS-CoV-2 nsp3 as a putative cause of the cytokine storm observed in the most severe cases of COVID-19" 32549200
both nsp2 and nsp3 are coded in orf1ab see 32083328
32083328 ä. COVID?2019: The role of the nsp2 and nsp3 in its pathogenesis
| 29128390 2018. Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein |
32578982 2020. Molecular Basis for ADP-ribose Binding to the Mac1 Domain of SARS-CoV-2 Nsp3.
| 32549200 2020. A Putative Role of de-Mono-ADP-Ribosylation of STAT1 by the SARS-CoV-2 Nsp3 Protein in the Cytokine Storm Syndrome of COVID-19. |
| 32563187 2020. Attenuated interferon and pro-inflammatory response in SARS-CoV-2-infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation. |
32828990 2020. The use of knowledge management tools in viroinformatics. Example study of a highly conserved sequence motif in Nsp3 of SARS-CoV-2 as a therapeutic target.
32835090 2020. In Silico Identification of Potential Inhibitors of ADP-Ribose Phosphatase of SARS-CoV-2 nsP3 by Combining E-Pharmacophore- and Receptor-Based Virtual Screening of Database.
32981460 2020. Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3.
33185784 2020. Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment.
