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| − | {{pnc}} | + | {{gohome}} |
| | + | {{ft|P}} |
| | + | '''CHERRYPICKING STUDIES IS NOT SCIENCE |
| | + | {{qt|Reviews on covid drug development}} |
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| − | current items will be put into the subsections.
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| − | subsections with contents are marked ''with content''.
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| − | the others are pending data.
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| − | *[[reviews on covid drug development]] ''with content'' | + | *'''[[scouting ideas]]''' |
| − | *[[scouting ideas]]
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| − | *[[Patients on biologicals]] | + | *'''[[PHA Biologicals]]''' |
| − | *[[HMGB1, RAGE]]
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| − | *[[pre-Interleukin 6]] ''with content''
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| − | *[[post-Interleukin 6]]
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| − | *[[pre-TNFalpha]]
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| − | *[[post-TNFalpha]]
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| − | *[[pre-Interleukin 17]]
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| − | *[[post-Interleukin 17]]
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| − | *[[pre-Interleukin 1]]
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| − | *[[post-Interleukin 1]]
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| − | *[[Inflammasome]]
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| − | *[[other anti-inflammatory]]
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| − | *[[NK-kappaB]]
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| − | *[[STAT 3]]
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| − | *[[JAK Janus Kinase]]
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| − | *[[Corticosteroids]]
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| − | *[[Cytokine absorbers]]
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| − | *[[Target Complement system]]
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| − | *[[Target Extracellular traps]]
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| − | *[[Anticoagulant in covid19]]
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| − | *[[Antioxidants]]
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| − | *[[Stem cells]]
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| − | *[[MDSC cells]]
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| − | *[[Interferons]]
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| | + | *'''[[PHA conventional pharmacology]]''' |
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| − | *[[other single compounds]] | + | *'''[[PHA retargeted compounds]]''' |
| − | *[[Retargeted single compounds]]
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| − | *[[Hydroxychloroquine]] ''with content''
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| − | *
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| − | *[[other antiviral compounds]] | + | *'''[[PHA antivirals by mechanism]]''' |
| − | *[[AV Remdesivir]]
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| − | *[[AV Lopinavir]]
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| − | *[[AV Ivermectin]]
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| − | *[[Target ACE2, Spike protein]] | + | *'''[[PHA pharmacophore by screened target]]''' |
| − | *[[Target TMPRSS2, Spike protein]]
| + | |
| | | | |
| | + | *'''[[PHA ImmunoNutrients]] |
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| | + | *'''[[PHA compl altern natural]]''' |
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| | + | *'''[[PHA within indications compounds]]''' |
| | | | |
| | + | *'''[[PHA Serum products]]''' |
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| | + | *'''[[PHA Vaccination]]''' |
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| | + | PHA related options: |
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| − | *[[Vitamin D]]
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| − |
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| − |
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| − | *[[Anorganic nutrients Magnesium]]
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| − | *[[Anorganic nutrients Selenium]]
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| − | *[[Anorganic nutrients Zinc]]
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| − | *[[Nutrition, general]]
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| − | *[[Exercise, Vibration]]
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| − |
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| − |
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| − | *[[Traditional Chinese Medicine]]
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| − | *[[Natural compounds]]
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| − |
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| − | *[[Statins]]
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| − | *[[Antidiabetic compounds, any]]
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| − | *[[RSP - On RAS drugs]]
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| − |
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| − | *[[Reconvalescent blood products, Passive vaccine]] ''with content''
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| − | *[[Plasmapheresis]]
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| − |
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| − | *[[Immunodeviation]] e.g. by adjuvants or other vaccinations
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| | *[[Radiation therapy]] | | *[[Radiation therapy]] |
| | *[[Phototherapy]] | | *[[Phototherapy]] |
| − | *[[Active vaccine]] ''with content'' | + | *[[Electric fields]] |
| − | | + | *[[Treatment other concepts]] |
| − | | + | |
| − | '''resilience enhancement'''
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| − | {{tp|p=32229705|t=2020. Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections |pdf=|usr=}}
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| − | {{tp|p=32311498|t=ä. The impact of nutrition on COVID-19 susceptibility and long-term consequences |pdf=|usr=}}
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| − | {{tp|p=32276453|t=2020. Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats |pdf=|usr=}}
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| − | | + | |
| − | '''psychoneuroimmunology'''
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| − | {{tp|p=32234338|t=ä. Using psychoneuroimmunity against COVID-19 |pdf=|usr=}}
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| − | '''Exercise'''
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| − | {{tp|p=32311497|t=ä. The immunological case for staying active during the COVID-19 pandemic |pdf=|usr=}}
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| − | | + | |
| − | '''Topical agents''' opening up the world of nano...
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| − | *[https://www.dailymail.co.uk/sciencetech/article-8315269/Commercial-mouthwash-prevent-COVID-19-transmission-scientists-say.html on mouth rinses] | + | |
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| − | {{tp|p=32305181|t=ä. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection |pdf=|usr=}}
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| − | | + | |
| − | {{tp|p=32325124|t=ä. Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals |pdf=|usr=}}
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| − | {{tp|p=32312129|t=2020. The role of additive manufacturing and antimicrobial polymers in the COVID-19 pandemic |pdf=|usr=}}
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| − | {{tp|p=32307559|t=ä. Management for patients with pediatric surgical disease during the COVID-19 epidemic |pdf=|usr=}}
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| − | {{tp|p=32247692|t=ä. Faecal-oral transmission of SARS-COV-2: practical implications |pdf=|usr=}}
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| − | {{tp|p=32367287|t=ä. New evidence of SARS-CoV-2 transmission through the ocular surface |pdf=|usr=}}
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| − | {{tp|p=32366728|t=2020. Medical Education During the COVID-19 Pandemic: A Single Institution Experience |pdf=|usr=}}
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| − | {{tp|p=32366726|t=2020. Management of Asthma in Children during COVID-19 Pandemic |pdf=|usr=}}
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| − | {{tp|p=32366725|t=2020. COVID -19 Pandemic: The Challenges for Pediatric Oncology |pdf=|usr=}}
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| − | {{tp|p=32282033|t=2020. Initiating adjunct low-dose hydroxyurea therapy for stroke prevention in children with SCA during the COVID-19 pandemic |pdf=|usr=}}
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| − | {{tp|p=32362106|t=2020. Management of conjunctivitis during the COVID-19 pandemic 2020 |pdf=|usr=}}
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| − | | + | |
| − | {{tp|p=32354030|t=2020. Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work |pdf=|usr=}}
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| − | {{tp|p=32336674|t=ä. COVID-19 Emergency Responders in FDA?s Center for Drug Evaluation and Research |pdf=|usr=}}
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| − | {{tp|p=32326426|t=2020. COVID-19: A Recommendation to Examine the Effect of Mouthrinses with beta-Cyclodextrin Combined with Citrox in Preventing Infection and Progression |pdf=|usr=}}
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| − | {{tp|p=32356251|t=ä. Medical Toxicology and COVID-19: Our Role in a Pandemic |pdf=|usr=}}
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| − | {{tp|p=32291198|t=2020. Impact of Nutrition and Diet on COVID-19 Infection and Implications for Kidney Health and Kidney Disease Management |pdf=|usr=}}
| + | |
| − | | + | |
| − | *''riociguat?''
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| − | {{tp|p=32340216|t=2020. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections |pdf=|usr=}}
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| − | {{tp|p=32342019|t=ä. Exercise against SARS-CoV-2 (COVID-19): Does workout intensity matter? (A mini review of some indirect evidence related to obesity) |pdf=|usr=}}
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| − | {{tp|p=32367847|t=2020. Nasopharyngeal wash in preventing and treating upper respiratory tract infections: Could it prevent COVID-19?|pdf=|usr=}}
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| − | {{tp|p=32243778|t=2020. Ensuring global access to COVID-19 vaccines |pdf=|usr=}}
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| − | {{tp|p=32247324|t=2020. Global coalition to accelerate COVID-19 clinical research in resource-limited settings |pdf=|usr=}}
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| − | {{tp|p=32326830|t=2020. Photobiomodulation and Antiviral Photodynamic Therapy as a Possible Novel Approach in COVID-19 Management |pdf=|usr=}}
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| − | {{tp|p=32330404|t=2020. Can Transdermal Photobiomodulation Help Us at the Time of COVID-19?|pdf=|usr=}}
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| − | {{tp|p=32272857|t=2020. Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks |pdf=|usr=}}
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| − | {{tp|p=C7190525|t=2020. Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients |pdf=|usr=}}
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| − | {{tp|p=32437659|t=2020. Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection |pdf=|usr=}}
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| − | {{tp|p=32129977|t=2020. Cell-Membrane-Mimicking Nanodecoys against Infectious Diseases |pdf=|usr=}}
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| − | {{tp|p=29115746|t=2018. Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies |pdf=|usr=}}
| + | |
| − | {{tp|p=29717819|t=2018. Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens |pdf=|usr=}}
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| − | {{tp|p=28945945|t=2017. Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses |pdf=|usr=}}
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| − | | + | |
| − | {{tp|p=21093489|t=2011. (x)Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model |pdf=|usr=}}
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| − | | + | |
| − | {{tp|p=C7194243|t=ä. Coronavirus Disease 2019 (COVID-19) Spread and Pharmacovigilance Implications: Expert Opinion |pdf=|usr=}}
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| − | {{tp|p=32383008|t=ä. The Role of Pharmacovigilance and ISoP During the Global COVID-19 Pandemic |pdf=|usr=}}
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| − | {{tp|p=32388486|t=2020. Light as a potential treatment for pandemic coronavirus infections: A perspective |pdf=|usr=}}
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| − | {{tp|p=32387334|t=ä. The Forrest Gump approach to preventing severe COVID-19 ? reverse the predisposing pro-inflammatory state with exercise |pdf=|usr=}}
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| − | {{tp|p=32380052|t=2020. Granulocyte-targeted therapies for airway diseases |pdf=|usr=}}
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| − | {{tp|p=32452420|t=2020. Antiviral activity of lycorine against Zika virus in vivo and in vitro |pdf=|usr=}}
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| | + | A concept of curative retargeting has been found by cellular lockdown with kinase inhibitors from the oncologic pharmacopoiea. |
| | + | This means, virus replication can be stalled to zero w/o need of develpoment of new substances. There is no need for world |
| | + | vaccination anymore. The virus needs permissible cells, and most perimissible is phosphotyrosine on its own compnents. |
| | + | Paper is (not yet in PubMed) : |
| | | | |
| | + | *'''[https://www.sciencedirect.com/science/article/pii/S1097276520305499?via%3Dihub Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication at Mol Cell 2020/08/11]''' |
| | + | credentials to [https://web.de/magazine/news/coronavirus/coronavirus-blockade-zellulaerer-kommunikation-forscher-stoppen-vermehrung-sars-cov-2-35045170 Marinus Brandl] who told us about it today. |
| | + | based on e.g. |
| | | | |
| | + | {{ttp|p=32408336|t=2020. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets |pdf=|usr=}} |
| | | | |
| | + | ======================================================================================= |
| | | | |
| | + | COVID19 is now a CURABLE disease !!! |
| | | | |
| − | {{tp|p=31930543|t=2020. Inactivation of three emerging viruses ? severe acute respiratory syndrome coronavirus, Crimean?Congo haemorrhagic fever virus and Nipah virus ? in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light |pdf=|usr=}}
| + | ======================================================================================= |
